Macrophages are a heterogeneous cell population playing a pivotal role in tissue
homeostasis and inflammation, and their phenotype strongly depends on the micromilieu …

BACKGROUND: Polarization of macrophages by specific micro-environmental conditions
impacts upon their function following subsequent activation. This study aimed to …

Macrophages possess the hallmark feature of plasticity, allowing them to undergo a dynamic
transition between M1 and M2 polarized phenotypes. The aim of the present study was to …

Macrophages are key cell types of the innate immune system regulating host defense,
inflammation, tissue homeostasis and cancer. Within this functional spectrum diverse and …

Monocytes/macrophages are heterogeneous and versatile cells that could undergo their
phenotypically/functionally dynamic switch in response to the microenvironment signals …

As an essential component of innate immunity, macrophages have multiple functions in both
inhibiting or promoting cell proliferation and tissue repair. Diversity and plasticity are …

Macrophages are unique cells for origin, heterogeneity and plasticity. At steady state most of
macrophages are derived from fetal sources and maintained in adulthood through self …

Macrophages are cells of the innate immunity constituting the mononuclear phagocyte
system and endowed with remarkable different roles essential for defense mechanisms …

Trained immunity is a form of innate immune memory best described in mice and humans.
Clear evidence of the evolutionary conservation of trained immunity in teleost fish is lacking …

Macrophages are key regulators of many organ systems, including innate and adaptive
immunity, systemic metabolism, hematopoiesis, vasculogenesis, malignancy, and …