Scavenger receptors on the cell surface of macrophages play an important role in host
defence through their ability to bind microbial ligands and induce phagocytosis …

Tissue repair is largely regulated by diverse Mϕ populations whose functions are timing-and
context-dependent. The early phase of healing is dominated by pro-inflammatory Mϕs, also …

MΦs display remarkable plasticity and the ability to activate diverse responses to a host of
intracellular and external stimuli. Despite extensive characterization of M1 MΦs and a broad …

Transgenic labeling of innate immune cell lineages within the larval zebrafish allows for real-
time, in vivo analyses of microbial pathogenesis within a vertebrate host. To date, labeling of …

Background Macrophage polarization has a causal role in the pathogenesis and resolution
of various clinical diseases. DNA-binding transcription factors (TFs) have been identified as …

In many parasitic infections both classically activated macrophages (caMF) and alternatively
activated macrophages (aaMF) play a pivotal role. To investigate if both types of …

Neutrophilic granulocytes and macrophages are crucial for the innate immune response
against infections. They migrate into the focus of inflammation, where they efficiently bind …

Teleost fish are indispensable model organisms for comparative immunology research that
should lead to an improved understanding of the general principles of vertebrate immune …

Little is known about the polarizing potential of currently used human macrophage cell lines,
while a better understanding phenomena can support the prediction of effects in vivo based …

Macrophages are cells with remarkable plasticity. They integrate signals from their
microenvironment leading to context-dependent polarization into classically (M1) or …