HPMA copolymers: origins, early developments, present, and future
J Kopeček, P Kopečková - Advanced drug delivery reviews, 2010 - Elsevier
The overview covers the discovery of N-(2-hydroxypropyl) methacrylamide (HPMA)
copolymers, initial studies on their synthesis, evaluation of biological properties, and …
copolymers, initial studies on their synthesis, evaluation of biological properties, and …
HPMA copolymer–anticancer drug conjugates: design, activity, and mechanism of action
The design, synthesis and properties of N-(2-hydroxypropyl) methacrylamide (HPMA)
copolymers as carriers of anticancer drugs are reviewed. Macromolecular therapeutics …
copolymers as carriers of anticancer drugs are reviewed. Macromolecular therapeutics …
Structural and chemical aspects of HPMA copolymers as drug carriers
K Ulbrich, V Šubr - Advanced drug delivery reviews, 2010 - Elsevier
Synthetic strategies and chemical and structural aspects of the synthesis of HPMA
copolymer conjugates with various drugs and other biologically active molecules are …
copolymer conjugates with various drugs and other biologically active molecules are …
HPMA copolymer-based nanomedicines in controlled drug delivery
Recently, numerous polymer materials have been employed as drug carrier systems in
medicinal research, and their detailed properties have been thoroughly evaluated. Water …
medicinal research, and their detailed properties have been thoroughly evaluated. Water …
Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities
R Duncan, MJ Vicent - Advanced drug delivery reviews, 2010 - Elsevier
N-(2-Hydroxypropyl) methacrylamide (HPMA) copolymer conjugates containing doxorubicin
designed in the late 1970s/early 1980s as anticancer polymer therapeutics were the first …
designed in the late 1970s/early 1980s as anticancer polymer therapeutics were the first …
Poly (N-(2-hydroxypropyl) methacrylamide)-based nanotherapeutics
BS Tucker, BS Sumerlin - Polymer Chemistry, 2014 - pubs.rsc.org
This mini-review provides a brief overview of recent advances in the area of biologically-
relevant nanomaterials composed of poly (N-(2-hydroxypropyl) methacrylamide)(PHPMA) …
relevant nanomaterials composed of poly (N-(2-hydroxypropyl) methacrylamide)(PHPMA) …
HPMA copolymer–drug conjugates with controlled tumor‐specific drug release
Over the past few decades, numerous polymer drug carrier systems are designed and
synthesized, and their properties are evaluated. Many of these systems are based on water …
synthesized, and their properties are evaluated. Many of these systems are based on water …
The light at the end of the tunnel—second generation HPMA conjugates for cancer treatment
It is almost four decades since N-(2-hydroxypropyl) methacrylamide (HPMA)-based
copolymers arose as drug carriers. Although fundamentals have been established and …
copolymers arose as drug carriers. Although fundamentals have been established and …
Improving the efficacy of combined modality anticancer therapy using HPMA copolymer-based nanomedicine formulations
T Lammers - Advanced drug delivery reviews, 2010 - Elsevier
Copolymers based on N-(2-hydroxypropyl) methacrylamide (HPMA) are prototypic and well-
characterized polymeric drug carriers that have been broadly implemented in the delivery of …
characterized polymeric drug carriers that have been broadly implemented in the delivery of …
Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers
T Lammers, R Kühnlein, M Kissel, V Subr… - Journal of controlled …, 2005 - Elsevier
Copolymers of N-(2-hydroxypropyl) methacrylamide (HPMA) are prototypic and well-
characterized polymeric drug carriers that are being broadly implemented in the delivery of …
characterized polymeric drug carriers that are being broadly implemented in the delivery of …