Limited utility of polymerase chain reaction in induced sputum specimens for determining the causes of childhood pneumonia in resource-poor settings: findings from …

DM Thea, P Seidenberg, DE Park… - Clinical Infectious …, 2017 - academic.oup.com
Background. Sputum examination can be useful in diagnosing the cause of pneumonia in
adults but is less well established in children. We sought to assess the diagnostic utility of …

The diagnostic utility of induced sputum microscopy and culture in childhood pneumonia

DR Murdoch, SC Morpeth, LL Hammitt… - Clinical infectious …, 2017 - academic.oup.com
Background. Sputum microscopy and culture are commonly used for diagnosing the cause
of pneumonia in adults but are rarely performed in children due to difficulties in obtaining …

Addressing the analytic challenges of cross-sectional pediatric pneumonia etiology data

LL Hammitt, DR Feikin, JAG Scott… - Clinical infectious …, 2017 - academic.oup.com
Despite tremendous advances in diagnostic laboratory technology, identifying the pathogen
(s) causing pneumonia remains challenging because the infected lung tissue cannot usually …

Induced sputum in the diagnosis of childhood community-acquired pneumonia

E Lahti, V Peltola, M Waris, R Virkki… - Thorax, 2009 - thorax.bmj.com
Background: The usefulness of induced sputum in searching for causative agents of
pneumonia in children has not been studied. Methods: The study involved 101 children …

The etiology of pneumonia from analysis of lung aspirate and pleural fluid samples: findings from the pneumonia etiology research for child health (PERCH) study

BE Ebruke, M Deloria Knoll, M Haddix… - Clinical Infectious …, 2021 - academic.oup.com
Background An improved understanding of childhood pneumonia etiology is required to
inform prevention and treatment strategies. Lung aspiration is the gold standard specimen …

The enduring challenge of determining pneumonia etiology in children: considerations for future research priorities

DR Feikin, LL Hammitt, DR Murdoch… - Clinical infectious …, 2017 - academic.oup.com
Pneumonia kills more children each year worldwide than any other disease. Nonetheless,
accurately determining the causes of childhood pneumonia has remained elusive. Over the …

A literature review and survey of childhood pneumonia etiology studies: 2000–2010

Z Gilani, YD Kwong, OS Levine… - Clinical infectious …, 2012 - academic.oup.com
Abstract The Pneumonia Etiology Research for Child Health (PERCH) project is the largest
multicountry etiology study of childhood pneumonia since the Board on Science and …

Etiology of childhood pneumonia: what we know, and what we need to know! Based on 5th Dr. IC Verma Excellence Oration Award

JL Mathew - The Indian Journal of Pediatrics, 2018 - Springer
Childhood community acquired pneumonia continues to be an important clinical problem at
the individual, institutional and community levels. Determination of microbial etiology is …

Microscopic analysis and quality assessment of induced sputum from children with pneumonia in the PERCH study

DR Murdoch, SC Morpeth, LL Hammitt… - Clinical infectious …, 2017 - academic.oup.com
Background. It is standard practice for laboratories to assess the cellular quality of
expectorated sputum specimens to check that they originated from the lower respiratory …

Utility of induced sputum in assessing bacterial etiology for community-acquired pneumonia in hospitalized children

A Green, JL Cockroft, RA Kaufman… - Journal of the …, 2022 - academic.oup.com
Background Diagnostic testing for bacterial etiology of community-acquired pneumonia
(CAP) is insensitive. Induced sputum (IS) is an attractive option for the evaluation of the …