Sickle cell hemoglobin (HbS) polymerization is considered to be the primary pathogenic
event in the sickle cell anemia. Many cellular and molecular factors have been identified so …

Although it has been known for more than 60 years that the cause of sickle cell disease is
polymerization of a hemoglobin mutant, hydroxyurea is the only drug approved for treatment …

Sickle cell disease is caused by a point mutation which allows sickle hemoglobin (HbS) to
form long fibers which distort blood cells, impeding circulation. HbS and fetal hemoglobin …

Sickle cell anaemia is associated with a mutant haemoglobin, HbS, which forms polymers in
the red blood cells of patients. The primary role of the HbS polymerization for the …

Using a combination of laser photolysis and temperature-jump techniques, the kinetics of
hemoglobin S polymerization have been studied over a wide range of delay times (10− 3 to …

Polymerization of sickle cell hemoglobin (HbS) in deoxy state is one of the basic events in
the pathophysiology of sickle cell anemia. For insight into the polymerization process, we …

Sickle cell anemia is a debilitating genetic disease that affects hundreds of thousands of
babies born each year worldwide. Its primary pathogenic event is the polymerization of a …

A cluster of amino acid residues located in the AB-GH region of the α-chain are shown in
intra-double strand axial interactions of the hemoglobin S (HbS) polymer. However, αLeu …