In their paper in the current issue of the British Journal of Haematology, Oksenberg et al
(2016) have taken a substantial step toward providing a second drug to treat the symptoms …

Abstract Background Deoxygenated sickle hemoglobin (HbS) polymerization drives the
pathophysiology of sickle cell disease. Therefore, direct inhibition of HbS polymerization has …

Hemoglobin is a complex system that undergoes conformational changes in response to
oxygen, allosteric effectors, mutations, and environmental changes. Here, we study allostery …

We have studied intracellular polymerization of hemoglobin S in suspensions of small
populations of sickle cells using circular polarized light scattering. We argue that the …

We have demonstrated that the extent of intracellular polymerization of deoxyhemoglobin S
can be predicted from knowledge of intracellular hemoglobin concentration, composition …

In an attempt to predict the likelihood of successfully treating sickle cell disease by
increasing haemoglobin S (Hb S) oxygen affinity, two liganded derivatives of Hb S have …

We have measured homogeneous and heterogeneous nucleation rates of sickle
hemoglobin (HbS) in the presence of a strongly binding deletion mutant of the cytoplasmic …

To provide quantitative information on the sites that promote polymerization of sickle
hemoglobin (HbS) after formation of the initial hydrophobic bond involving Val-6 (β)[E6V (β)] …

For insights into the mechanisms of heme action on the rate of sickle cell hemoglobin
polymerization, we determine the erythrocytic concentration of free heme using a novel …