Summary BA. 2.86, a recently described sublineage of SARS-CoV-2 Omicron, contains
many mutations in the spike gene. It appears to have originated from BA. 2 and is distinct …

SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD)
that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep …

The current global pandemic of COVID-19 is caused by a novel coronavirus SARS-CoV-2.
The SARS-CoV-2 spike protein receptor-binding domain (RBD) is the critical determinant of …

SARS-CoV-2 can mutate to evade immunity, with consequences for the efficacy of emerging
vaccines and antibody therapeutics. Herein we demonstrate that the immunodominant …

SARS-CoV-2 is continually evolving, with more contagious mutations spreading rapidly.
Using in vitro evolution to affinity maturate the receptor-binding domain (RBD) of the spike …

Global efforts are being made to monitor the evolution of SARS-CoV-2, aiming for early
identification of genotypes providing increased infectivity or virulence. However, viral …

Many SARS-CoV-2 variants with naturally acquired mutations have emerged. These
mutations can affect viral properties such as infectivity and immune resistance. Although the …

The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral
attachment to ACE2 receptor and is a major determinant of host range and a dominant target …

Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike
receptor-binding domain (RBD) may alter viral host tropism and affect the activities of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a global health
crisis after its emergence in 2019. Replication of the virus is initiated by binding of the viral …