[HTML][HTML] Omicron: Master of immune evasion maintains robust ACE2 binding
M Hoffmann, L Zhang, S Pöhlmann - Signal Transduction and Targeted …, 2022 - nature.com
The spike (S) protein of the SARS-CoV-2 Omicron variant is highly mutated but the impact of
these mutations on viral entry into cells and its inhibition by antibodies has been unclear. A …
these mutations on viral entry into cells and its inhibition by antibodies has been unclear. A …
Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity
Monitoring the mutation dynamics of SARS-CoV-2 is critical for the development of effective
approaches to contain the pathogen. By analyzing 106 SARS-CoV-2 and 39 SARS genome …
approaches to contain the pathogen. By analyzing 106 SARS-CoV-2 and 39 SARS genome …
[HTML][HTML] Characterisation of B. 1.1. 7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2.
The recent emergence of SARS-CoV-2 variants with increased transmission, pathogenesis
and immune resistance has jeopardised the global response to the COVID-19 pandemic …
and immune resistance has jeopardised the global response to the COVID-19 pandemic …
SARS-CoV-2 omicron BA. 2.87. 1 exhibits higher susceptibility to serum neutralization than EG. 5.1 and JN. 1
As SARS-CoV-2 continues to spread and mutate, tracking the viral evolutionary trajectory
and understanding the functional consequences of its mutations remain crucial. Here, we …
and understanding the functional consequences of its mutations remain crucial. Here, we …
[HTML][HTML] Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility
A spike protein mutation D614G became dominant in SARS-CoV-2 during the COVID-19
pandemic. However, the mutational impact on viral spread and vaccine efficacy remains to …
pandemic. However, the mutational impact on viral spread and vaccine efficacy remains to …
[HTML][HTML] Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging
vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS …
vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS …
Immune evasion and ACE2 binding affinity contribute to SARS-CoV-2 evolution
Mutations in the SARS-CoV-2 genome could confer resistance to pre-existing antibodies
and/or increased transmissibility. The recently emerged Omicron subvariants exhibit a …
and/or increased transmissibility. The recently emerged Omicron subvariants exhibit a …
Naturally mutated spike proteins of SARS-CoV-2 variants show differential levels of cell entry
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is steadily mutating during continuous …
respiratory syndrome coronavirus 2 (SARS-CoV-2), is steadily mutating during continuous …
[HTML][HTML] Perspectives: SARS-CoV-2 spike convergent evolution as a guide to explore adaptive advantage
Viruses rapidly co-evolve with their hosts. The 9 million sequenced SARS-CoV-2 genomes
by March 2022 provide a detailed account of viral evolution, showing that all amino acids …
by March 2022 provide a detailed account of viral evolution, showing that all amino acids …
[HTML][HTML] A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike
B Dadonaite, KHD Crawford, CE Radford, AG Farrell… - Cell, 2023 - cell.com
A major challenge in understanding SARS-CoV-2 evolution is interpreting the antigenic and
functional effects of emerging mutations in the viral spike protein. Here, we describe a deep …
functional effects of emerging mutations in the viral spike protein. Here, we describe a deep …