Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail
The SARS-CoV-2 pandemic has led to an urgent need to understand the molecular basis for
immune recognition of SARS-CoV-2 spike (S) glycoprotein antigenic sites. To define the …
immune recognition of SARS-CoV-2 spike (S) glycoprotein antigenic sites. To define the …
[HTML][HTML] SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility
During the evolution of SARS-CoV-2 in humans a D614G substitution in the spike (S) protein
emerged and became the predominant circulating variant (S-614G) of the COVID-19 …
emerged and became the predominant circulating variant (S-614G) of the COVID-19 …
[HTML][HTML] Structural modeling of the SARS-CoV-2 spike/human ACE2 complex interface can identify high-affinity variants associated with increased transmissibility
HH Gan, A Twaddle, B Marchand… - Journal of Molecular …, 2021 - Elsevier
The COVID-19 pandemic has triggered concerns about the emergence of more infectious
and pathogenic viral strains. As a public health measure, efficient screening methods are …
and pathogenic viral strains. As a public health measure, efficient screening methods are …
[HTML][HTML] Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity
SY Gong, D Chatterjee, J Richard, J Prévost, A Tauzin… - Virology, 2021 - Elsevier
Towards the end of 2020, multiple variants of concern (VOCs) and variants of interest (VOIs)
have arisen from the original SARS-CoV-2 Wuhan-Hu-1 strain. Mutations in the Spike …
have arisen from the original SARS-CoV-2 Wuhan-Hu-1 strain. Mutations in the Spike …
Coordinated evolution at amino acid sites of sars-cov-2 spike
AD Neverov, G Fedonin, A Popova, D Bykova… - Elife, 2023 - elifesciences.org
SARS-CoV-2 has adapted in a stepwise manner, with multiple beneficial mutations
accumulating in a rapid succession at origins of VOCs, and the reasons for this are unclear …
accumulating in a rapid succession at origins of VOCs, and the reasons for this are unclear …
[HTML][HTML] Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwide
The COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2), was declared on March 11, 2020 by the World Health Organization. As of the …
(SARS-CoV-2), was declared on March 11, 2020 by the World Health Organization. As of the …
[HTML][HTML] SARS-CoV-2 rapidly evolves lineage-specific phenotypic differences when passaged repeatedly in immune-naive mice
JDS Willett, A Gravel, I Dubuc, L Gudimard… - Communications …, 2024 - nature.com
The persistence of SARS-CoV-2 despite the development of vaccines and a degree of herd
immunity is partly due to viral evolution reducing vaccine and treatment efficacy. Serial …
immunity is partly due to viral evolution reducing vaccine and treatment efficacy. Serial …
V367F mutation in SARS-CoV-2 spike RBD emerging during the early transmission phase enhances viral infectivity through increased human ACE2 receptor binding …
J Ou, Z Zhou, R Dai, J Zhang, S Zhao, X Wu… - Journal of …, 2021 - Am Soc Microbiol
The current pandemic of COVID-19 is caused by a novel coronavirus, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 spike protein receptor …
respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 spike protein receptor …
[HTML][HTML] The D614G mutation in the SARS-CoV2 Spike protein increases infectivity in an ACE2 receptor dependent manner.
The SARS-CoV2 coronavirus responsible for the current COVID19 pandemic has been
reported to have a relatively low mutation rate. Nevertheless, a few prevalent variants have …
reported to have a relatively low mutation rate. Nevertheless, a few prevalent variants have …
[HTML][HTML] The effect of spike mutations on SARS-CoV-2 neutralization
C Rees-Spear, L Muir, SA Griffith, J Heaney, Y Aldon… - Cell reports, 2021 - cell.com
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines show
protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the …
protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the …