Interrogating a high-density SNP map for signatures of natural selection
Identifying genomic regions that have been targets of natural selection remains one of the
most important and challenging areas of research in genetics. To this end, we report an …
most important and challenging areas of research in genetics. To this end, we report an …
Genomic signatures of positive selection in humans and the limits of outlier approaches
Identifying regions of the human genome that have been targets of positive selection will
provide important insights into recent human evolutionary history and may facilitate the …
provide important insights into recent human evolutionary history and may facilitate the …
Population history and natural selection shape patterns of genetic variation in 132 genes
Identifying regions of the human genome that have been targets of natural selection will
provide important insights into human evolutionary history and may facilitate the …
provide important insights into human evolutionary history and may facilitate the …
Detecting natural selection in genomic data
JJ Vitti, SR Grossman, PC Sabeti - Annual review of genetics, 2013 - annualreviews.org
The past fifty years have seen the development and application of numerous statistical
methods to identify genomic regions that appear to be shaped by natural selection. These …
methods to identify genomic regions that appear to be shaped by natural selection. These …
1000 Genomes Selection Browser 1.0: a genome browser dedicated to signatures of natural selection in modern humans
M Pybus, GM Dall'Olio, P Luisi, M Uzkudun… - Nucleic acids …, 2014 - academic.oup.com
Searching for Darwinian selection in natural populations has been the focus of a multitude of
studies over the last decades. Here we present the 1000 Genomes Selection Browser 1.0 …
studies over the last decades. Here we present the 1000 Genomes Selection Browser 1.0 …
Genome-wide signals of positive selection in human evolution
The role of positive selection in human evolution remains controversial. On the one hand,
scans for positive selection have identified hundreds of candidate loci, and the genome …
scans for positive selection have identified hundreds of candidate loci, and the genome …
Exploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets
Genome-wide scans for selection have identified multiple regions of the human genome as
being targeted by positive selection. However, only a small proportion has been replicated …
being targeted by positive selection. However, only a small proportion has been replicated …
Population genetic inference from genomic sequence variation
Population genetics has evolved from a theory-driven field with little empirical data into a
data-driven discipline in which genome-scale data sets test the limits of available models …
data-driven discipline in which genome-scale data sets test the limits of available models …
Positive natural selection in the human lineage
Positive natural selection is the force that drives the increase in prevalence of advantageous
traits, and it has played a central role in our development as a species. Until recently, the …
traits, and it has played a central role in our development as a species. Until recently, the …
Detecting genomic signatures of natural selection with principal component analysis: application to the 1000 genomes data
N Duforet-Frebourg, K Luu, G Laval… - Molecular biology …, 2016 - academic.oup.com
To characterize natural selection, various analytical methods for detecting candidate
genomic regions have been developed. We propose to perform genome-wide scans of …
genomic regions have been developed. We propose to perform genome-wide scans of …
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