Interrogating a high-density SNP map for signatures of natural selection

JM Akey, G Zhang, K Zhang, L Jin… - Genome research, 2002 - genome.cshlp.org
Identifying genomic regions that have been targets of natural selection remains one of the
most important and challenging areas of research in genetics. To this end, we report an …

Genomic signatures of positive selection in humans and the limits of outlier approaches

JL Kelley, J Madeoy, JC Calhoun, W Swanson… - Genome …, 2006 - genome.cshlp.org
Identifying regions of the human genome that have been targets of positive selection will
provide important insights into recent human evolutionary history and may facilitate the …

Population history and natural selection shape patterns of genetic variation in 132 genes

JM Akey, MA Eberle, MJ Rieder, CS Carlson… - PLoS …, 2004 - journals.plos.org
Identifying regions of the human genome that have been targets of natural selection will
provide important insights into human evolutionary history and may facilitate the …

Detecting natural selection in genomic data

JJ Vitti, SR Grossman, PC Sabeti - Annual review of genetics, 2013 - annualreviews.org
The past fifty years have seen the development and application of numerous statistical
methods to identify genomic regions that appear to be shaped by natural selection. These …

1000 Genomes Selection Browser 1.0: a genome browser dedicated to signatures of natural selection in modern humans

M Pybus, GM Dall'Olio, P Luisi, M Uzkudun… - Nucleic acids …, 2014 - academic.oup.com
Searching for Darwinian selection in natural populations has been the focus of a multitude of
studies over the last decades. Here we present the 1000 Genomes Selection Browser 1.0 …

Genome-wide signals of positive selection in human evolution

D Enard, PW Messer, DA Petrov - Genome research, 2014 - genome.cshlp.org
The role of positive selection in human evolution remains controversial. On the one hand,
scans for positive selection have identified hundreds of candidate loci, and the genome …

Exploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets

M Fagny, E Patin, D Enard, LB Barreiro… - Molecular biology …, 2014 - academic.oup.com
Genome-wide scans for selection have identified multiple regions of the human genome as
being targeted by positive selection. However, only a small proportion has been replicated …

Population genetic inference from genomic sequence variation

JE Pool, I Hellmann, JD Jensen, R Nielsen - Genome research, 2010 - genome.cshlp.org
Population genetics has evolved from a theory-driven field with little empirical data into a
data-driven discipline in which genome-scale data sets test the limits of available models …

Positive natural selection in the human lineage

PC Sabeti, SF Schaffner, B Fry, J Lohmueller, P Varilly… - science, 2006 - science.org
Positive natural selection is the force that drives the increase in prevalence of advantageous
traits, and it has played a central role in our development as a species. Until recently, the …

Detecting genomic signatures of natural selection with principal component analysis: application to the 1000 genomes data

N Duforet-Frebourg, K Luu, G Laval… - Molecular biology …, 2016 - academic.oup.com
To characterize natural selection, various analytical methods for detecting candidate
genomic regions have been developed. We propose to perform genome-wide scans of …