Although it is well established that the presence of nutrients in the gut lumen can bring about
changes in GI function, the mechanisms and pathways by which these changes occur has …

Recent advances highlight that nutrient receptors (such as T1R1/T1R3 heterodimer, Ca
sensing receptor and GPR93 for amino acids and protein, GPR40, GPR41, GPR43 and …

The enteric nervous system (ENS) integrates numerous sensory signals in order to control
and maintain normal gut functions. Nutrients are one of the prominent factors which …

The chemical environment of the intestinal lumen and the presence of nutrients in the gut
result in the secretion of regulatory peptides and in the discharge of intestinal sensory …

Targeting the intestinal nutrient-sensing machinery by dietary and/or pharmacological
means holds promises in particular for treatment of type 2 diabetes. This interest may help to …

The release of gut hormones involved in the control of food intake is dependent on the acute
nutritional status of the body, suggesting that chemosensory mechanisms are involved in the …

Mechanical and chemical stimulation of the gastrointestinal mucosa exerts negative and
positive feedback regulation of secretory and motor function of the gastrointestinal tract. The …

The mechanisms by which the gut senses and responds to nutrients involve the interplay of
multiple complex pathways. In addition to regulating digestion and absorption, the pathways …

Highlights•Luminal chemical substances are sensed by the duodenal mucosa by multiple
mechanisms.•Nutrient sensing triggers gut hormone release to control local regulation of …

Highlights•Gastrointestinal nutrient sensors detect macronutrient break-down
products.•Nutrient sensing by enteroendocrine cells alters appetite-regulating hormone …