In the context of OA disease, NF-κB transcription factors can be triggered by a host of stress-
related stimuli including pro-inflammatory cytokines, excessive mechanical stress and ECM …

Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …

The family of nuclear factor-kappaB (NF-κB) transcription factors is intimately involved in the
regulation of expression of numerous genes in the setting of the inflammatory response …

Nuclear factor-kappaB (NF-κB) proteins constitute a family of transcription factors that are
stimulated by pro-inflammatory cytokines, chemokines, stress-related factors and …

Recent advances in our understanding of the role of cytokine networks in inflammatory
processes have led to the development of novel biological agents for the treatment of …

In the synovial cells of patients with RA, activation of the nuclear factor-κB (NF-κB) pathway
results in the transactivation of a multitude of responsive genes that contribute to the …

Osteoarthritis (OA), a whole-joint disease driven by abnormal biomechanics and attendant
cell-derived and tissue-derived factors, is a rheumatic disease with the highest prevalence …

Signaling via NF-κB is a key process during inflammation and thus constitutes an attractive
target for anti-inflammatory therapeutic interventions. Especially during initial …

Inflammation is a defensive mechanism for pathogen clearance and maintaining tissue
homeostasis. In the skeletal system, inflammation is closely associated with many bone …

The NF-κB (nuclear factor κB) family of transcription factors are involved in a myriad of
activities, including the regulation of immune responses, maturation of immune cells …