Uptake of botulinum neurotoxin into cultured neurons
JE Keller, F Cai, EA Neale - Biochemistry, 2004 - ACS Publications
Botulinum neurotoxins (BoNTs) act within the synaptic terminal to block neurotransmitter
release. The toxin enters the neuron by binding to neuronal membrane receptor (s), being …
release. The toxin enters the neuron by binding to neuronal membrane receptor (s), being …
Development of cell-based assays to measure botulinum neurotoxin serotype A activity using cleavage-sensitive antibodies
JE Nuss, G Ruthel, LE Tressler… - Journal of …, 2010 - journals.sagepub.com
Botulinum neurotoxins (BoNTs) are zinc-metalloproteases that cleave components of the
SNARE (soluble N-ethylmaleimidesensitive factor attachment protein receptor) protein …
SNARE (soluble N-ethylmaleimidesensitive factor attachment protein receptor) protein …
Action mechanisms of botulinum neurotoxins and tetanus neurotoxins
F Deloye, F Doussau, B Poulain - … des Séances de la Société de …, 1997 - europepmc.org
Tetanus (TeNT) neurotoxin and botulinum (BoNT, serotypes AG) neurotoxins are di-chain
bacterial proteins of MW-150 kDa which are also termed as clostridial neurotoxins. They are …
bacterial proteins of MW-150 kDa which are also termed as clostridial neurotoxins. They are …
Transynaptic action of botulinum neurotoxin type A at central cholinergic boutons
Botulinum neurotoxin Type A (BoNT/A) is an effective treatment for several movement
disorders, including spasticity and dystonia. BoNT/A acts by cleaving synaptosomal …
disorders, including spasticity and dystonia. BoNT/A acts by cleaving synaptosomal …
[HTML][HTML] Endocytosis, trafficking and exocytosis of intact full-length botulinum neurotoxin type a in cultured rat neurons
LS Valois, KA Wilkinson, Y Nakamura, JM Henley - Neurotoxicology, 2020 - Elsevier
Abstract Botulinum toxin A (BoNT/A) is a potent neurotoxin that acts primarily by silencing
synaptic transmission by blocking neurotransmitter release. BoNT/A comprises a light chain …
synaptic transmission by blocking neurotransmitter release. BoNT/A comprises a light chain …
Botulinum and tetanus neurotoxins: emerging tools for the study of membrane fusion
R Jahn, PI Hanson, H Otto… - Cold Spring Harbor …, 1995 - symposium.cshlp.org
Neurons release their neurotransmitters by means of exocytosis of synaptic vesicles. To
accomplish this goal, neurons possess a highly specialized pathway of membrane recycling …
accomplish this goal, neurons possess a highly specialized pathway of membrane recycling …
Botulinum neurotoxins can enter cultured neurons independent of synaptic vesicle recycling
S Pellett, WH Tepp, JM Scherf, EA Johnson - PLoS One, 2015 - journals.plos.org
Botulinum neurotoxins (BoNTs) are the causative agent of the severe and long-lasting
disease botulism. At least seven different serotypes of BoNTs (denoted AG) have been …
disease botulism. At least seven different serotypes of BoNTs (denoted AG) have been …
Atoxic derivative of botulinum neurotoxin A as a prototype molecular vehicle for targeted delivery to the neuronal cytoplasm
EJ Vazquez-Cintron, M Vakulenko, PA Band… - PLoS …, 2014 - journals.plos.org
We have previously described genetic constructs and expression systems that enable facile
production of recombinant derivatives of botulinum neurotoxins (BoNTs) that retain the …
production of recombinant derivatives of botulinum neurotoxins (BoNTs) that retain the …
[HTML][HTML] Botulinum neurotoxin, an example of successful translational research
J Segura-Aguilar, Y Tizabi - Clinical pharmacology and …, 2018 - ncbi.nlm.nih.gov
One of the major problems in medicine is the difficulties in translating preclinical research
into successful clinical studies and new therapies. It is evident that understanding the …
into successful clinical studies and new therapies. It is evident that understanding the …