Tel: 608–263–6806 Fax: 608–263–1114 E-mail: brdasgup@ wisc. edu Abbreviations: NT,
neurotoxin; L-chain, light chain; H-chain, heavy chain; SNARE, soluble N-ethylmaleimide …

Botulinum neurotoxin (BoNT), for more than a hundred years, has been a recognized
poisonous principle in spoiled food. As its chemical structure became unraveled, and as …

Botulinum neurotoxins (BoNTs) and some animal neurotoxins (β-Bungarotoxin, β-Btx, from
elapid snakes and α-Latrotoxin, α-Ltx, from black widow spiders) are pre-synaptic …

Botulinum neurotoxins (BoNTs) rank amongst the most potent toxins known. The factors
responsible for the emergence of the many known and yet unknown BoNT variants remain …

Botulinum neurotoxin type A (BoNT/A) is a metalloprotease that produces a sustained yet
transitory blockade of transmitter release from peripheral nerve terminals. Local delivery of …

Botulinum neurotoxins (BoNTs) are the most potent natural toxins known. The effects of
BoNT serotype A (BoNT/A) can last several months, whereas the effects of BoNT serotype E …

Botulinum neurotoxins are a unique group of metalloproteases which catalyze single site
cleavage of specific proteins involved in the docking and fusion of synaptic vesicles with …

The action of a botulinum neurotoxin (BoNT) commences by binding at the nerve terminal
via its H-(heavy) chain to a cell-surface receptor, which consists of a ganglioside and a cell …

The extraordinarily potent clostridial neurotoxins (CNTs) comprise tetanus neurotoxin
(TeNT) and the seven established botulinum neurotoxin serotypes (BoNT/AG). They are …

The high potency of the botulinum neurotoxins (BoNT) and tetanus neurotoxin (TeNT) is
mainly due to their neurospecific binding which is mediated by the interaction with two …