Structural evolution of SARS-CoV-2 omicron in human receptor recognition

W Zhang, K Shi, Q Geng, M Herbst, M Wang… - Journal of …, 2023 - Am Soc Microbiol
Understanding the evolutionary strategies of the SARS-CoV-2 omicron variant is crucial for
comprehending the COVID-19 pandemic and preventing future coronavirus pandemics. In …

Vaccine-escape and fast-growing mutations in the United Kingdom, the United States, Singapore, Spain, India, and other COVID-19-devastated countries

R Wang, J Chen, K Gao, GW Wei - Genomics, 2021 - Elsevier
Abstract Recently, the SARS-CoV-2 variants from the United Kingdom (UK), South Africa,
and Brazil have received much attention for their increased infectivity, potentially high …

Emergence and rapid transmission of SARS-CoV-2 B. 1.1. 7 in the United States

NL Washington, K Gangavarapu, M Zeller, A Bolze… - Cell, 2021 - cell.com
Summary The highly transmissible B. 1.1. 7 variant of SARS-CoV-2, first identified in the
United Kingdom, has gained a foothold across the world. Using S gene target failure (SGTF) …

Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events

J Ou, W Lan, X Wu, T Zhao, B Duan, P Yang… - … and Targeted Therapy, 2022 - nature.com
The current pandemic of COVID-19 is fueled by more infectious emergent Omicron variants.
Ongoing concerns of emergent variants include possible recombinants, as genome …

Coordinated evolution at amino acid sites of sars-cov-2 spike

AD Neverov, G Fedonin, A Popova, D Bykova… - Elife, 2023 - elifesciences.org
SARS-CoV-2 has adapted in a stepwise manner, with multiple beneficial mutations
accumulating in a rapid succession at origins of VOCs, and the reasons for this are unclear …

SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution

J Zahradník, S Marciano, M Shemesh, E Zoler… - Nature …, 2021 - nature.com
SARS-CoV-2 variants of interest and concern will continue to emerge for the duration of the
COVID-19 pandemic. To map mutations in the receptor-binding domain (RBD) of the spike …

Neutralization of SARS-CoV-2 variants of concern harboring Q677H

C Zeng, JP Evans, JN Faraone, P Qu, YM Zheng, L Saif… - MBio, 2021 - Am Soc Microbiol
The sensitivity of SARS-CoV-2 variants of concern (VOCs) to neutralizing antibodies has
largely been studied in the context of key receptor binding domain (RBD) mutations …

Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA. 1

A Moulana, T Dupic, AM Phillips, J Chang… - Nature …, 2022 - nature.com
The Omicron BA. 1 variant emerged in late 2021 and quickly spread across the world.
Compared to the earlier SARS-CoV-2 variants, BA. 1 has many mutations, some of which …

Balancing functional tradeoffs between protein stability and ACE2 binding in the SARS-CoV-2 omicron BA. 2, BA. 2.75 and XBB lineages: dynamics-based network …

G Verkhivker, M Alshahrani, G Gupta - Viruses, 2023 - mdpi.com
Evolutionary and functional studies suggested that the emergence of the Omicron variants
can be determined by multiple fitness trade-offs including the immune escape, binding …

[HTML][HTML] Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

JA Plante, Y Liu, J Liu, H Xia, BA Johnson… - BioRxiv, 2020 - ncbi.nlm.nih.gov
A spike protein mutation D614G became dominant in SARS-CoV-2 during the COVID-19
pandemic. However, the mutational impact on viral spread and vaccine efficacy remains to …