[HTML][HTML] Understanding the driving forces that trigger mutations in SARS-CoV-2: mutational energetics and the role of arginine blockers in COVID-19 therapy
H Ridgway, CT Chasapis, K Kelaidonis, I Ligielli… - Viruses, 2022 - mdpi.com
SARS-CoV-2 is a global challenge due to its ability to mutate into variants that spread more
rapidly than the wild-type virus. Because the molecular biology of this virus has been studied …
rapidly than the wild-type virus. Because the molecular biology of this virus has been studied …
As COVID-19 cases surge, here's what to know about JN. 1, the latest SARS-CoV-2 “Variant of Interest”
R Rubin - Jama, 2024 - jamanetwork.com
When BA. 2.86 joined the SARS-CoV-2 Omicron family last summer, it grabbed pandemic
trackers' attention because it was so different from its progenitor, BA. 2. Compared with BA …
trackers' attention because it was so different from its progenitor, BA. 2. Compared with BA …
Molecular dynamic simulation reveals E484K mutation enhances spike RBD-ACE2 affinity and the combination of E484K, K417N and N501Y mutations (501Y. V2 …
G Nelson, O Buzko, P Spilman, K Niazi, S Rabizadeh… - BioRxiv, 2021 - biorxiv.org
Rapidly spreading SARS-CoV-2 variants present not only an increased threat to human
health due to the confirmed greater transmissibility of several of these new strains but, due to …
health due to the confirmed greater transmissibility of several of these new strains but, due to …
[HTML][HTML] Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants
Abstract In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified,
and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that …
and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that …
Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics
SARS-CoV-2 emergent variants are characterized by increased viral fitness and each shows
multiple mutations predominantly localized to the spike (S) protein. Here, amide …
multiple mutations predominantly localized to the spike (S) protein. Here, amide …
Evolution of the SARS-CoV-2 mutational spectrum
SARS-CoV-2 evolves rapidly in part because of its high mutation rate. Here, we examine
whether this mutational process itself has changed during viral evolution. To do this, we …
whether this mutational process itself has changed during viral evolution. To do this, we …
SARS-CoV-2 variants of concern in the United States—challenges and opportunities
RP Walensky, HT Walke, AS Fauci - Jama, 2021 - jamanetwork.com
On January 10, 2020, the first genomic sequence of the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) isolated from a patient in Wuhan, China, was posted online. As …
coronavirus 2 (SARS-CoV-2) isolated from a patient in Wuhan, China, was posted online. As …
Single-virus tracking reveals variant SARS-CoV-2 spike proteins induce ACE2-independent membrane interactions
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a global health
crisis after its emergence in 2019. Replication of the virus is initiated by binding of the viral …
crisis after its emergence in 2019. Replication of the virus is initiated by binding of the viral …
[HTML][HTML] Making sense of mutation: what D614G means for the COVID-19 pandemic remains unclear
In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein
D614G rapidly became dominant around the world. Although clinical and in vitro data …
D614G rapidly became dominant around the world. Although clinical and in vitro data …
[PDF][PDF] The B1. 351 and P. 1 variants extend SARS-CoV-2 host range to mice
X Montagutelli, M Prot, L Levillayer, EB Salazar… - BioRxiv, 2021 - biorxiv.org
Receptor recognition is a major determinant of viral host range, as well as infectivity and
pathogenesis. Emergences have been associated with serendipitous events of adaptation …
pathogenesis. Emergences have been associated with serendipitous events of adaptation …