Purpose: We used 31P magnetic resonance spectroscopy (MRS) and near-infrared
spectroscopy (NIRS) as a means of quantifying abnormalities in calf muscle oxygenation …

Objective: Decreased oxygen supply is generally accepted as the primary cause of muscle
dysfunction in patients with peripheral arterial occlusive disease (PAOD) and intermittent …

1. We set out to define abnormalities of oxidative ATP synthesis, cellular proton efflux and
the efficiency of ATP usage in gastrocnemius muscle of patients with claudication due to …

Background Clinical assessments of peripheral artery disease (PAD) severity are insensitive
to pathophysiological changes in muscle tissue oxygenation and energy metabolism distal …

OBJECTIVE: Discrete morphologic, enzymatic and functional changes in skeletal muscle
mitochondria have been demonstrated in patients with peripheral arterial disease (PAD). We …

In exercising muscle, creatine kinase ensures that mismatch between ATP supply and ATP
use results in net phosphocreatine (PCr) splitting. This, inter alia, makes 31 P magnetic …

In peripheral vascular disease, impaired muscle energy metabolism is assumed to be due
mainly to defective vascular O2 supply, the resulting cellular hypoxia inhibiting oxidative …

OBJECTIVES:(1) To review the available information on mitochondrial function in type 2
diabetes mellitus (T2DM) and peripheral arterial disease (PAD) obtained by non-invasive …

Evidence suggests that the peak skeletal muscle mitochondrial ATP synthesis rate (V max)
in patients with peripheral artery disease (PAD) may be attenuated due to disease-related …

Objective Myopathy, characterised by altered mitochondrial function, is a central part of the
pathophysiology of peripheral arterial disease and the aim of this study was to investigate …