Macro‐autophagy is an ancient and highly conserved self‐degradative process that plays a
homeostatic role in normal cells by eliminating organelles, pathogens, and protein …

Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

Autophagy is a highly conserved self-degradative process that has a key role in cellular
stress responses and survival. Recent work has begun to explore the function of autophagy …

During tumorigenesis, cancer cells are exposed to a wide variety of intrinsic and extrinsic
stresses that challenge homeostasis and growth. Cancer cells display activation of distinct …

Autophagy is a lysosomal degradation pathway that acts as a dynamic regulator of
tumorigenesis. Specifically, autophagy has been shown to impede early cancer …

The functional relevance of autophagy in tumor formation and progression remains
controversial. Autophagy can promote tumor suppression during cancer initiation and …

Macroautophagy/autophagy is a fundamental cellular degradation mechanism that
maintains cell homeostasis, regulates cell signaling, and promotes cell survival. Its role in …

Macroautophagy is the process by which cells package and degrade cytosolic components,
and recycle the breakdown products for future use. Since its initial description by Christian …

Macroautophagy is a cellular quality-control process that degrades proteins, protein
aggregates and damaged organelles. Autophagy plays a fundamental role in cancer where …

In order to metastasize, tumor cells must adapt to untoward, stressful microenvironments as
they disseminate into the systemic circulation and colonize distant organ sites. Autophagy, a …