Functions of autophagy in the tumor microenvironment and cancer metastasis
EE Mowers, MN Sharifi, KF Macleod - The FEBS journal, 2018 - Wiley Online Library
Macro‐autophagy is an ancient and highly conserved self‐degradative process that plays a
homeostatic role in normal cells by eliminating organelles, pathogens, and protein …
homeostatic role in normal cells by eliminating organelles, pathogens, and protein …
Autophagy and autophagy-related pathways in cancer
Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …
Autophagy in cancer metastasis
EE Mowers, MN Sharifi, KF Macleod - Oncogene, 2017 - nature.com
Autophagy is a highly conserved self-degradative process that has a key role in cellular
stress responses and survival. Recent work has begun to explore the function of autophagy …
stress responses and survival. Recent work has begun to explore the function of autophagy …
The double-edge sword of autophagy in cancer: from tumor suppression to pro-tumor activity
R Chavez-Dominguez, M Perez-Medina… - Frontiers in …, 2020 - frontiersin.org
During tumorigenesis, cancer cells are exposed to a wide variety of intrinsic and extrinsic
stresses that challenge homeostasis and growth. Cancer cells display activation of distinct …
stresses that challenge homeostasis and growth. Cancer cells display activation of distinct …
Cellular and metabolic functions for autophagy in cancer cells
CM Kenific, J Debnath - Trends in cell biology, 2015 - cell.com
Autophagy is a lysosomal degradation pathway that acts as a dynamic regulator of
tumorigenesis. Specifically, autophagy has been shown to impede early cancer …
tumorigenesis. Specifically, autophagy has been shown to impede early cancer …
Autophagy: cancer's friend or foe?
The functional relevance of autophagy in tumor formation and progression remains
controversial. Autophagy can promote tumor suppression during cancer initiation and …
controversial. Autophagy can promote tumor suppression during cancer initiation and …
Mechanisms and context underlying the role of autophagy in cancer metastasis
Macroautophagy/autophagy is a fundamental cellular degradation mechanism that
maintains cell homeostasis, regulates cell signaling, and promotes cell survival. Its role in …
maintains cell homeostasis, regulates cell signaling, and promotes cell survival. Its role in …
Autophagy in cancer: a complex relationship
L Wilde, K Tanson, J Curry… - Biochemical …, 2018 - portlandpress.com
Macroautophagy is the process by which cells package and degrade cytosolic components,
and recycle the breakdown products for future use. Since its initial description by Christian …
and recycle the breakdown products for future use. Since its initial description by Christian …
Impact of context-dependent autophagy states on tumor progression
M Assi, AC Kimmelman - Nature cancer, 2023 - nature.com
Macroautophagy is a cellular quality-control process that degrades proteins, protein
aggregates and damaged organelles. Autophagy plays a fundamental role in cancer where …
aggregates and damaged organelles. Autophagy plays a fundamental role in cancer where …
Autophagy and metastasis: another double-edged sword
In order to metastasize, tumor cells must adapt to untoward, stressful microenvironments as
they disseminate into the systemic circulation and colonize distant organ sites. Autophagy, a …
they disseminate into the systemic circulation and colonize distant organ sites. Autophagy, a …