A growing literature indicates that mitochondria are key participants in innate immune
pathways, functioning as both signaling platforms and contributing to effector responses. In …

The innate immune system has a key role in the mammalian immune response. Recent
research has demonstrated that mitochondria participate in a broad range of innate immune …

Canonical functions of mitochondria include the regulation of cellular survival, orchestration
of anabolic and metabolic pathways, as well as reactive oxygen species (ROS) signaling …

Mitochondria are intracellular organelles that originate from a bacterial symbiont, and they
retain multiple features of this bacterial ancestry. The immune system evolved to detect the …

Mitochondria are functionally versatile organelles. In addition to their conventional role of
meeting the cell's energy requirements, mitochondria also actively regulate innate immune …

Maintaining mitochondrial health is essential for the survival and function of eukaryotic
organisms. Misfunctioning mitochondria activate stress-responsive pathways to restore …

Mitochondrial dysfunction is associated with the manifestation and origin of a plethora of
diseases and disorders. Whilst classically the role of these archetypical 'powerhouses' in …

Mitochondria are master regulators of metabolism and have emerged as key signalling
organelles of the innate immune system. Each mitochondrion harbours potent agonists of …

Mitochondria are versatile organelles and essential components of numerous biological
processes such as energy metabolism, signal transduction, and cell fate determination. In …

Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …