Early and delayed aspects of nuclear reprogramming during cloning
KE Latham - Biology of the Cell, 2005 - Wiley Online Library
The successful production of viable progeny following adult somatic cell nuclear transfer
(cloning) provides exciting new opportunities for basic research for investigating early …
(cloning) provides exciting new opportunities for basic research for investigating early …
Nuclear cloning, stem cells, and genomic reprogramming
R Jaenisch, K Eggan, D Humpherys… - Cloning & Stem …, 2002 - liebertpub.com
The generation of adult animals by nuclear cloning from adult donor cells is extremely
inefficient, with most clones dying soon after implantation. In contrast, cloning from …
inefficient, with most clones dying soon after implantation. In contrast, cloning from …
Cloning: new breakthroughs leading to commercial opportunities
SL Stice, JM Robl, FAP De Leon, J Jerry, PG Golueke… - Theriogenology, 1998 - Elsevier
Research on cloning animals, again, came to the forefront of public attention in 1997. Most
scientists involved in biomedical and agricultural research have emphasized the benefits, of …
scientists involved in biomedical and agricultural research have emphasized the benefits, of …
New advances in somatic cell nuclear transfer: application in transgenesis
IA Polejaeva, KHS Campbell - Theriogenology, 2000 - Elsevier
The ability to produce live offspring by nuclear transfer from cultured somatic cells provides a
route for the precise genetic manipulation of large animal species. Such modifications …
route for the precise genetic manipulation of large animal species. Such modifications …
Reshaping the transcriptional frontier: epigenetics and somatic cell nuclear transfer
CR Long, ME Westhusin… - Molecular reproduction …, 2014 - Wiley Online Library
Somatic‐cell nuclear transfer (SCNT) experiments have paved the way to the field of cellular
reprogramming. The demonstrated ability to clone over 20 different species to date has …
reprogramming. The demonstrated ability to clone over 20 different species to date has …
Reprogramming in nuclear transfer
A Jouneau, JP Renard - Current opinion in genetics & development, 2003 - Elsevier
Reprogramming a nucleus by transferring it to oocyte cytoplasm triggers epigenetic changes
that eventually lead to the restoration of a totipotent state and the birth of a viable animal. A …
that eventually lead to the restoration of a totipotent state and the birth of a viable animal. A …
Efficiencies and mechanisms of nuclear reprogramming
V Pasque, K Miyamoto… - Cold Spring Harbor …, 2010 - symposium.cshlp.org
The differentiated state of somatic cells is highly stable, but it can be experimentally
reversed. The resulting cells can then be redirected into many different pathways. Nuclear …
reversed. The resulting cells can then be redirected into many different pathways. Nuclear …
Cloning: questions answered and unsolved
KE Latham - Differentiation, 2004 - Wiley Online Library
Cloning by the transfer of adult somatic cell nuclei to oocytes has produced viable offspring
in a variety of mammalian species. The technology is still in its initial stages of development …
in a variety of mammalian species. The technology is still in its initial stages of development …
Nuclear-cytoplasmic “tug of war” during cloning: effects of somatic cell nuclei on culture medium preferences of preimplantation cloned mouse embryos
YG Chung, MRW Mann, MS Bartolomei… - Biology of …, 2002 - academic.oup.com
Cloning by somatic cell nuclear transfer is critically dependent upon early events that occur
immediately after nuclear transfer, and possibly additional events that occur in the cleaving …
immediately after nuclear transfer, and possibly additional events that occur in the cleaving …
From nuclear transfer to nuclear reprogramming: the reversal of cell differentiation
JB Gurdon - Annu. Rev. Cell Dev. Biol., 2006 - annualreviews.org
This is a personal historical account of events leading from the earliest success in vertebrate
nuclear transfer to the current hope that nuclear reprogramming may facilitate cell …
nuclear transfer to the current hope that nuclear reprogramming may facilitate cell …