The successful production of viable progeny following adult somatic cell nuclear transfer
(cloning) provides exciting new opportunities for basic research for investigating early …

The generation of adult animals by nuclear cloning from adult donor cells is extremely
inefficient, with most clones dying soon after implantation. In contrast, cloning from …

Research on cloning animals, again, came to the forefront of public attention in 1997. Most
scientists involved in biomedical and agricultural research have emphasized the benefits, of …

The ability to produce live offspring by nuclear transfer from cultured somatic cells provides a
route for the precise genetic manipulation of large animal species. Such modifications …

Somatic‐cell nuclear transfer (SCNT) experiments have paved the way to the field of cellular
reprogramming. The demonstrated ability to clone over 20 different species to date has …

Reprogramming a nucleus by transferring it to oocyte cytoplasm triggers epigenetic changes
that eventually lead to the restoration of a totipotent state and the birth of a viable animal. A …

The differentiated state of somatic cells is highly stable, but it can be experimentally
reversed. The resulting cells can then be redirected into many different pathways. Nuclear …

Cloning by the transfer of adult somatic cell nuclei to oocytes has produced viable offspring
in a variety of mammalian species. The technology is still in its initial stages of development …

Cloning by somatic cell nuclear transfer is critically dependent upon early events that occur
immediately after nuclear transfer, and possibly additional events that occur in the cleaving …

This is a personal historical account of events leading from the earliest success in vertebrate
nuclear transfer to the current hope that nuclear reprogramming may facilitate cell …