Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy

L Qian, PM Flood, JS Hong - Journal of neural transmission, 2010 - Springer
Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by the
progressive loss of dopaminergic neurons in the substantia nigra and depletion of dopamine …

[HTML][HTML] Neuroinflammation in Parkinson's disease and its potential as therapeutic target

Q Wang, Y Liu, J Zhou - Translational neurodegeneration, 2015 - Springer
Abstract Parkinson's disease (PD), the second most common age-associated
neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and …

[HTML][HTML] Microglia mediated neuroinflammation in Parkinson's disease

S Isik, B Yeman Kiyak, R Akbayir, R Seyhali, T Arpaci - Cells, 2023 - mdpi.com
Parkinson's Disease (PD) is the second most common neurodegenerative disorder seen,
especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance …

[HTML][HTML] Neuroinflammation and Parkinson's disease—From neurodegeneration to therapeutic opportunities

B Araújo, R Caridade-Silva, C Soares-Guedes… - Cells, 2022 - mdpi.com
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder
worldwide. Clinically, it is characterized by a progressive degeneration of dopaminergic …

[HTML][HTML] Inflammation in Parkinson's disease: mechanisms and therapeutic implications

M Pajares, A I. Rojo, G Manda, L Boscá, A Cuadrado - Cells, 2020 - mdpi.com
Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …

Significant roles of neuroinflammation in Parkinson's disease: therapeutic targets for PD prevention

Y Lee, S Lee, SC Chang, J Lee - Archives of pharmacal research, 2019 - Springer
Glial cells outnumber neurons in the brain and play important roles in the neuroinflammation
that accompanies brain damage in neurodegenerative diseases. In Parkinson's disease …

Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention

MG Tansey, MS Goldberg - Neurobiology of disease, 2010 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disease, after
Alzheimer's disease. The potential causes of PD remain uncertain, but recent studies …

[HTML][HTML] Neurodegeneration and neuroinflammation in Parkinson's disease: a self-sustained loop

G Arena, K Sharma, G Agyeah, R Krüger… - Current Neurology and …, 2022 - Springer
Abstract Purpose of Review Neuroinflammation plays a significant role in Parkinson's
disease (PD) etiology along with mitochondrial dysfunction and impaired proteostasis. In this …

The role of neuroinflammation on the pathogenesis of Parkinson's disease

YC Chung, HW Ko, EG Bok, ES Park, SH Huh… - BMB …, 2010 - koreascience.kr
Parkinson's Disease (PD) is a common neurodegenerative disease characterized by the
progressive degeneration of nigrostriatal dopaminergic (DA) neurons. Although the …

Microglia in Parkinson's disease

MS Ho - Neuroglia in neurodegenerative diseases, 2019 - Springer
Microglia are the most abundant immune cells in the central nervous system (CNS), where
they interact with neurons and exhibit a wide array of functions in physiological and …