“Virtual”(computed) fractional flow reserve: current challenges and limitations

PD Morris, FN van de Vosse, PV Lawford… - JACC: Cardiovascular …, 2015 - jacc.org
Fractional flow reserve (FFR) is the “gold standard” for assessing the physiological
significance of coronary artery disease during invasive coronary angiography. FFR-guided …

Fast virtual fractional flow reserve based upon steady-state computational fluid dynamics analysis: results from the VIRTU-Fast study

PD Morris, DA Silva Soto, JFA Feher, D Rafiroiu… - Basic to Translational …, 2017 - jacc.org
Fractional flow reserve (FFR)-guided percutaneous intervention is superior to standard
assessment but remains underused. The authors have developed a novel “pseudotransient” …

Accuracy of computational pressure-fluid dynamics applied to coronary angiography to derive fractional flow reserve: FLASH FFR

J Li, Y Gong, W Wang, Q Yang, B Liu, Y Lu… - Cardiovascular …, 2020 - academic.oup.com
Aims Conventional fractional flow reserve (FFR) is measured invasively using a coronary
guidewire equipped with a pressure sensor. A non-invasive derived FFR would eliminate …

[HTML][HTML] Vessel fractional flow reserve (vFFR) for the assessment of stenosis severity: the FAST II study

K Masdjedi, N Tanaka, E Van Belle, S Porouchani… - …, 2022 - ncbi.nlm.nih.gov
Background Fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI)
is superior to angiography-guided PCI. The clinical uptake of FFR has been limited …

Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve …

PD Morris, D Ryan, AC Morton, R Lycett… - JACC: Cardiovascular …, 2013 - jacc.org
Objectives: The aim of this study was to develop a computer model that accurately predicts
myocardial fractional flow reserve (FFR) from angiographic images alone, in patients with …

Projected costs and consequences of computed tomography‐determined fractional flow reserve

MA Hlatky, A Saxena, BK Koo, A Erglis… - Clinical …, 2013 - Wiley Online Library
Background Randomized trials have shown that fractional flow reserve (FFR) guided
percutaneous coronary intervention (PCI) improves clinical outcome and reduces costs …

Long-term outcomes of fractional flow reserve-guided vs. angiography-guided percutaneous coronary intervention in contemporary practice

J Li, MY Elrashidi, AJ Flammer, RJ Lennon… - European heart …, 2013 - academic.oup.com
Aims Fractional flow reserve (FFR) is the reference standard for the assessment of the
functional significance of coronary artery stenoses, but is underutilized in daily clinical …

Accuracy of fractional flow reserve derived from coronary angiography

WF Fearon, S Achenbach, T Engstrom, A Assali… - Circulation, 2019 - Am Heart Assoc
Background: Measuring fractional flow reserve (FFR) with a pressure wire remains
underutilized because of the invasiveness of guide wire placement or the need for a …

Angiography‐derived fractional flow reserve: More or less physiology?

PD Morris, N Curzen, JP Gunn - Journal of the American Heart …, 2020 - Am Heart Assoc
Evidence robustly demonstrates that ischemia, rather than anatomy, is the optimal target for
coronary revascularization. In the cardiac catheter laboratory, fractional flow reserve (FFR) …

The Evolution of Virtual Physiologic Assessments and Virtual Coronary Intervention to Optimize Revascularization

KM Stout, KD Boudoulas, TJ Povsic, SE Altin… - Current Cardiovascular …, 2021 - Springer
Abstract Purpose of Review In this review, we summarize the use of virtual physiologic
functional assessments of coronary artery disease and their utility to guide virtual coronary …