The new antigen receptor (IgNAR) family has been detected in all elasmobranch species so
far studied and has several intriguing structural and functional features. IgNAR protein …

The new antigen receptor (IgNAR) antibodies from sharks are disulphide bonded dimers of
two protein chains, each containing one variable and five constant domains. Three types of …

Sharks express an unusual heavy-chain isotype called IgNAR, whose variable regions bind
antigen as independent soluble domains. To further probe affinity maturation of the IgNAR …

The new antigen receptor (NAR) gene in the nurse shark diversifies extensively by somatic
hypermutation. It is not known, however, whether NAR somatic hypermutation generates the …

The Ig new antigen receptors (IgNARs) are single-domain antibodies found in the serum of
sharks. Here, we report 2.2-and 2.8-Å structures of the type 2 IgNAR variable domains 12Y-1 …

The immunoglobulin new antigen receptors (IgNARs) are a class of Ig-like molecules of the
shark immune system that exist as heavy chain-only homodimers and bind antigens by their …

We recently have identified an antigen receptor in sharks called NAR (n ew or n urse shark a
ntigen r eceptor) that is secreted by splenocytes but does not associate with Ig light (L) …

Using a degenerate oligonucleotide primer specific for immunoglobulin (Ig) constant type 1
(C‐1 set) domain genes, products were amplified by the reverse transcriptase‐polymerase …

The cartilaginous fish are the oldest phylogenetic group in which Igs have been found.
Sharks produce a unique Ig isotype, IgNAR, a heavy-chain homodimer that does not …

Shark is a cartilaginous fish that produces new antigen receptor (IgNAR) antibodies. This
antibody is identified with a similar human heavy chain but dissimilar sequences. The …