Galanin and spinal nociceptive mechanisms: recent results from transgenic and knock-out models
Z Wiesenfeld-Hallin, XJ Xu, JN Crawley, T Hökfelt - Neuropeptides, 2005 - Elsevier
Genetically modified mice with transgenic overexpression of galanin or depletion of genes
for galanin or galanin receptors have become available, providing a new approach for …
for galanin or galanin receptors have become available, providing a new approach for …
Endogenous galanin potentiates spinal nociceptive processing following inflammation
We have undertaken a series of experiments using galanin null mutant mice to better define
the role of endogenous galanin in spinal excitability following inflammation and in response …
the role of endogenous galanin in spinal excitability following inflammation and in response …
Mice over-expressing galanin have elevated heat nociceptive threshold
KH Blakeman, K Holmberg, JX Hao, X Xu, U Kahl… - …, 2001 - journals.lww.com
The neuropeptide galanin may have a role in modulation of nociceptive input at spinal level.
Here we report that mice over-expressing galanin exhibit significant elevation of nociceptive …
Here we report that mice over-expressing galanin exhibit significant elevation of nociceptive …
Hyperalgesia and increased neuropathic pain-like response in mice lacking galanin receptor 1 receptors
KH Blakeman, JX Hao, XJ Xu, AS Jacoby, J Shine… - Neuroscience, 2003 - Elsevier
The neuropeptide galanin may have a role in modulation of nociception, particularly after
peripheral nerve injury. The effect of galanin is mediated by at least three subtypes of …
peripheral nerve injury. The effect of galanin is mediated by at least three subtypes of …
The participation of galanin in pain processing at the spinal level
Abstract Galanin, a 29-amino-acid peptide expressed in dorsal root ganglia (DRG) and
spinal dorsal horn interneurones, is regulated by nerve injury and peripheral inflammation …
spinal dorsal horn interneurones, is regulated by nerve injury and peripheral inflammation …
Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor
Background: Galanin is expressed in a small percentage of intact small diameter sensory
neurons of the dorsal root ganglia and in the afferent terminals of the superficial lamina of …
neurons of the dorsal root ganglia and in the afferent terminals of the superficial lamina of …
Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia
Background: Galanin is expressed at low levels in the intact sensory neurons of the dorsal
root ganglia with a dramatic increase after peripheral nerve injury. The neuropeptide is also …
root ganglia with a dramatic increase after peripheral nerve injury. The neuropeptide is also …
Galanin over-expression decreases the development of neuropathic pain-like behaviors in mice after partial sciatic nerve injury
K Hygge-Blakeman, P Brumovsky, JX Hao, XJ Xu… - Brain research, 2004 - Elsevier
The neuropeptide galanin may have a role in modulation of nociception, particularly after
peripheral nerve injury. Here we assessed the development of neuropathic pain-like …
peripheral nerve injury. Here we assessed the development of neuropathic pain-like …
Galanin and spinal nociceptive mechanisms: recent advances and therapeutic implications
XJ Xu, T Hökfelt, T Bartfai, Z Wiesenfeld-Hallin - Neuropeptides, 2000 - Elsevier
Galanin is a peptide consisting of 29 or 30 (in humans) amino acids that is present in
sensory and spinal dorsal horn neurons. Endogenous galanin may have an important …
sensory and spinal dorsal horn neurons. Endogenous galanin may have an important …
Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury
BJ Kerr, WBJ Cafferty, YIK Gupta… - European Journal of …, 2000 - Wiley Online Library
The neuropeptide galanin has been identified as a potential neurotransmitter/
neuromodulator within the central nervous system. In the present study, the role of …
neuromodulator within the central nervous system. In the present study, the role of …