This review celebrates the 30th anniversary of the first in vivo near-infrared (NIR)
spectroscopy (NIRS) publication, which was authored by Professor Frans Jöbsis. At first …

The feasibility of non-invasive analysis of brain activities was studied in the attempt to
overcome the major limitation of actual in vivo methodologies ie invasiveness. Optic fibre …

A novel magnetic-resonance-coupled broadband near-infrared (NIR) tomography system for
small animal brain studies is described. Several features of the image formation approach …

We present and validate a multi-wavelength time-domain near-infrared spectroscopy (TD-
NIRS) system that avoids switching wavelengths and instead exploits the full capability of a …

Functional near-infrared spectroscopy (fNIRS) is a noninvasive optical imaging technique
that indirectly assesses neuronal activity by measuring changes in oxygenated and …

This review is aimed at celebrating the upcoming 20th anniversary of the birth of human
functional near-infrared spectroscopy (fNIRS). After the discovery in 1992 that the functional …

In healthy human adults, cerebral concentrations of oxygenated hemoglobin ([HbO 2]) and
deoxygenated hemoglobin ([HbR]) were assessed during brain activation using near …

The present paper demonstrates functional brain mapping with an optical imaging technique
by using tissue-transparent near-infrared light. With a maximal five-channel optical …

The fundamentals of near infrared spectroscopy (NIRS) are reviewed. This technique allows
to measure the oxygenation of the brain tissue. The particular problems involved in detecting …

A time-resolved optical instrument allowing for noninvasive assessment of cerebral
oxygenation is presented. The instrument is equipped with picosecond diode lasers, fast …