Neuroprotective effects of resveratrol and epigallocatechin gallate polyphenols are mediated by the activation of protein kinase C gamma

C Menard, S Bastianetto, R Quirion - Frontiers in cellular …, 2013 - frontiersin.org
Polyphenols such as epigallocatechin gallate (EGCG) and resveratrol have received a great
deal of attention because they may contribute to the purported neuroprotective action of the …

Comparative neuroprotective properties of stilbene and catechin analogs: action via a plasma membrane receptor site?

S Bastianetto, Y Dumont, Y Han… - CNS neuroscience & …, 2009 - Wiley Online Library
Various studies have reported on the neuroprotective effects of polyphenols, widely present
in food, beverages, and natural products. For example, we have shown that resveratrol, a …

Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (‐)‐epigallocatechin‐3‐gallate: implications for neurodegenerative diseases

S Mandel, O Weinreb, T Amit… - Journal of …, 2004 - Wiley Online Library
Accumulating evidence supports the hypothesis that brain iron misregulation and oxidative
stress (OS), resulting in reactive oxygen species (ROS) generation from H2O2 and …

Alzheimer's disease and green tea: epigallocatechin-3-gallate as a modulator of inflammation and oxidative stress

V Valverde-Salazar, D Ruiz-Gabarre… - Antioxidants, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia, characterised by a
marked decline of both memory and cognition, along with pathophysiological hallmarks …

Resveratrol prevents CA1 neurons against ischemic injury by parallel modulation of both GSK‐3β and CREB through PI3‐K/Akt pathways

F Simão, A Matté, AS Pagnussat… - European Journal of …, 2012 - Wiley Online Library
Accumulating evidence indicates that resveratrol potently protects against cerebral ischemia
damage due to its oxygen free radicals scavenging and antioxidant properties. However …

The “French Paradox” and beyond: neuroprotective effects of polyphenols

AY Sun, A Simonyi, GY Sun - Free Radical Biology and Medicine, 2002 - Elsevier
Chronic ethanol ingestion is known to cause oxidative damage to a number of organs
including the brain. This is partly due to the ability of ethanol to enhance oxygen free radical …

Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (−)-epigallocatechin 3-gallate neuroprotective action

Y Levites, T Amit, MBH Youdim, S Mandel - Journal of biological chemistry, 2002 - ASBMB
Studies from our laboratory have demonstrated that the major green tea polyphenol,(−)-
epigallocatechin 3-gallate (EGCG), exerts potent neuroprotective actions in the mice model …

Neuroprotective effects of natural products: interaction with intracellular kinases, amyloid peptides and a possible role for transthyretin

S Bastianetto, J Brouillette, R Quirion - Neurochemical Research, 2007 - Springer
Various studies reported on the neuroprotective effects of natural products, particularly
polyphenols, widely present in food and beverages. For example, we have shown that …

Botanical phenolics and brain health

AY Sun, Q Wang, A Simonyi, GY Sun - Neuromolecular medicine, 2008 - Springer
The high demand for molecular oxygen, the enrichment of polyunsaturated fatty acids in
membrane phospholipids, and the relatively low abundance of antioxidant defense enzymes …

Epigallocatechin-3-Gallate (EGCG): New therapeutic perspectives for neuroprotection, aging, and neuroinflammation for the modern age

A Payne, S Nahashon, E Taka, GM Adinew… - Biomolecules, 2022 - mdpi.com
Alzheimer's and Parkinson's diseases are the two most common forms of neurodegenerative
diseases. The exact etiology of these disorders is not well known; however, environmental …