Olopatadine is a human conjunctival mast cell stabilizer with anti‐histaminic activity.
Ketotifen is an older molecule that possesses antihistaminic activity and is reported to have …

Objective: Olopatadine, an effective topical ocular human conjunctival mast cell stabilizer/
antihistaminic antiallergic drug, was evaluated and compared to selected classical …

Ketotifen relieves the symptoms of allergic conjunctivitis through multiple mechanisms of
action. One such mechanism may involve stabilization of conjunctival mast cells. Because of …

Background: Histamine receptor activation and degranulation of mast cells are the
mechanisms by which the ocular itching, hyperemia, chemosis, eyelid swelling, and tearing …

Objective: The purpose of this study was to assess the effects of olopatadine on the release
of mast cell-derived mediators after conjunctival allergen challenge (CAC) in humans …

ABSTRACT Olopatadine (AL-4943A; KW-4679)[(z)-11-[3-(dimethylamino) propylidene]-6, 11-
dihydrodibenz [b, e] oxepine-2 acetic acid hydrochloride] is an anti-allergic agent which …

BACKGROUND: The concept of mast cell heterogeneity is well established. Recent data
indicate that human conjunctival tissue mast cells and human connective tissue mast cells …

Olopatadine (AL-4943A; KW-4679)[(Z)-11-[3-(dimethylamino) propylidene]-6, 11-
dihydrodibenz [b, e] oxepine-2-acetic acid hydrochloride] is an antiallergic/antihistaminic …

Ocular allergies are very common and range in intensity from mild, self-resolving, acute
conditions to serious, chronic disease that can severely affect vision. The vast majority of …

Importance of the field: Ocular allergic diseases are characterized by specific activation of
conjunctival mast cells with subsequent release of preformed and newly formed mediators …