Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models
Microglia and complement can mediate neurodegeneration in Alzheimer's disease (AD). By
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of
microglia and complement in AD has been attributed to neuroinflammation, prominent late in …
microglia and complement in AD has been attributed to neuroinflammation, prominent late in …
Astrocyte-microglia cross talk through complement activation modulates amyloid pathology in mouse models of Alzheimer's disease
H Lian, A Litvinchuk, ACA Chiang… - Journal of …, 2016 - Soc Neuroscience
Increasing evidence supports a role of neuroinflammation in the pathogenesis of
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …
Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models
Complement is involved in developmental synaptic pruning and pathological synapse loss
in Alzheimer's disease. It is posited that C1 binding initiates complement activation on …
in Alzheimer's disease. It is posited that C1 binding initiates complement activation on …
Blockage of CR1 prevents activation of rodent microglia
H Crehan, J Hardy, J Pocock - Neurobiology of disease, 2013 - Elsevier
The importance of the complement system in Alzheimer's disease (AD) pathogenesis has
been emphasized through recent genome wide association studies. However, the cellular …
been emphasized through recent genome wide association studies. However, the cellular …
Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice
Q Shi, S Chowdhury, R Ma, KX Le, S Hong… - Science translational …, 2017 - science.org
The complement cascade not only is an innate immune response that enables removal of
pathogens but also plays an important role in microglia-mediated synaptic refinement during …
pathogens but also plays an important role in microglia-mediated synaptic refinement during …
Complement C3aR inactivation attenuates tau pathology and reverses an immune network deregulated in tauopathy models and Alzheimer's disease
A Litvinchuk, YW Wan, DB Swartzlander, F Chen… - Neuron, 2018 - cell.com
Strong evidence implicates the complement pathway as an important contributor to amyloid
pathology in Alzheimer's disease (AD); however, the role of complement in tau modulation …
pathology in Alzheimer's disease (AD); however, the role of complement in tau modulation …
Synaptic mitochondrial dysfunction and septin accumulation are linked to complement-mediated synapse loss in an Alzheimer's disease animal model
BA Györffy, V Tóth, G Török, P Gulyássy… - Cellular and Molecular …, 2020 - Springer
Synaptic functional disturbances with concomitant synapse loss represent central
pathological hallmarks of Alzheimer's disease. Excessive accumulation of cytotoxic amyloid …
pathological hallmarks of Alzheimer's disease. Excessive accumulation of cytotoxic amyloid …
[HTML][HTML] Complement C3 is activated in human AD brain and is required for neurodegeneration in mouse models of amyloidosis and tauopathy
T Wu, B Dejanovic, VD Gandham, A Gogineni… - Cell reports, 2019 - cell.com
Complement pathway overactivation can lead to neuronal damage in various neurological
diseases. Although Alzheimer's disease (AD) is characterized by β-amyloid plaques and tau …
diseases. Although Alzheimer's disease (AD) is characterized by β-amyloid plaques and tau …
Inflammation in Alzheimer's disease: lessons learned from microglia-depletion models
EE Spangenberg, KN Green - Brain, behavior, and immunity, 2017 - Elsevier
Microglia are the primary immune cell of the brain and function to protect the central nervous
system (CNS) from injury and invading pathogens. In the homeostatic brain, microglia serve …
system (CNS) from injury and invading pathogens. In the homeostatic brain, microglia serve …
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