Contributing to the on-going debate around the clinical application of preimplantation embryo selection based on polygenic risk scores (PGT-P)

P Makrythanasis, G Kakourou, T Mamas… - European Journal of …, 2023 - nature.com
The article by Siermann et al.[1] in this issue presents the findings of a questionnaire-based
survey of 31 health care professionals (HCPs) involved in Preimplantation Genetic Testing …

Ready for polygenic risk scores? An analysis of regulation of preimplantation genetic testing in European countries

M Siermann, V van der Schoot, EM Bunnik… - Human …, 2024 - academic.oup.com
STUDY QUESTION Would the different regulatory approaches for preimplantation genetic
testing (PGT) in Europe permit the implementation of preimplantation genetic testing using …

Limitations, concerns and potential: attitudes of healthcare professionals toward preimplantation genetic testing using polygenic risk scores

M Siermann, O Valcke, JR Vermeesch… - European Journal of …, 2023 - nature.com
Preimplantation genetic testing using polygenic risk scores (PGT-P) has recently been
introduced. However, PGT-P has been met with many ethical concerns. It is therefore …

Clinical utility of polygenic risk scores for embryo selection: a points to consider statement of the American College of Medical Genetics and Genomics (ACMG)

TA Grebe, G Khushf, JM Greally, P Turley, N Foyouzi… - Genetics in …, 2024 - Elsevier
Polygenic risk score (PRS) assessment for embryo selection (hereafter referred to as
preimplantation testing for polygenic disorder [PGT-P]) is an emerging reproductive …

The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

F Forzano, O Antonova, A Clarke, G de Wert… - European Journal of …, 2022 - nature.com
Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private
testing companies to parents using in vitro fertilisation as being useful in selecting the …

P-337 Ready for polygenic risk scores? An analysis of regulation of preimplantation genetic testing in seven European countries

M Siermann, V Van der Schoot, E Bunnik… - Human …, 2024 - academic.oup.com
Study question Would the different regulatory approaches for preimplantation genetic testing
(PGT) in Europe permit the implementation of preimplantation genetic testing using …

“Are we not going too far?“: Socio-ethical considerations of preimplantation genetic testing using polygenic risk scores according to healthcare professionals

M Siermann, O Valcke, JR Vermeesch, T Raivio… - Social Science & …, 2024 - Elsevier
The recent introduction of polygenic risk scores within preimplantation genetic testing (PGT-
P) has been met with many concerns. To get more insights into the perspectives of relevant …

Perspectives of preimplantation genetic testing patients in Belgium on the ethics of polygenic embryo screening

M Siermann, JR Vermeesch, T Raivio, A Vanhie… - Reproductive …, 2024 - Elsevier
Research question What are the perspectives of preimplantation genetic testing (PGT)
patients in Belgium on the ethics of PGT for polygenic risk scoring (PGT-P)? Design In-depth …

[HTML][HTML] A review of normative documents on preimplantation genetic testing: recommendations for PGT-P

M Siermann, O Tšuiko, JR Vermeesch, T Raivio… - Genetics in …, 2022 - Elsevier
Purpose Recently, preimplantation genetic testing (PGT) for polygenic conditions (PGT-P)
has been introduced commercially. In view of the lack of specific guidance on this …

Correction: The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

F Forzano, O Antonova, A Clarke, G de Wert… - European Journal of …, 2022 - nature.com
The article “The use of polygenic risk scores in pre-implantation genetic testing: an
unproven, unethical practice”, written by Francesca Forzano et al., was originally published …