Navigating the Solution to Drug Formulation Problems at Research and Development Stages by Amorphous Solid Dispersion Technology.

D Tripathi, BH MP, J Sahoo, J Kumari - Recent Advances in Drug …, 2023 - europepmc.org
Amorphous Solid Dispersions (ASDs) have indeed revolutionized the pharmaceutical
industry, particularly in drug solubility enhancement. The amorphous state of a drug, which …

Manufacturing Amorphous Solid Dispersions With Improved Solid-State Stability

SV Bhujbal - 2021 - hammer.purdue.edu
Although amorphous solid dispersion (ASD) is a promising strategy for enhancing drug
solubility, it has not been recognized to its full potential due to a lack of understanding as to …

[图书][B] Physical stability and crystallization inhibition

LS Taylor - 2015 - books.google.com
In order to successfully utilize amorphous solid dispersions (ASDs) to enhance drug
delivery, it is essential to maintain the amorphous form of the drug during the manufacturing …

Characterization of amorphous solid dispersions: An update

X Ma, RO Williams III - Journal of Drug Delivery Science and Technology, 2019 - Elsevier
Amorphous solid dispersions (ASDs) are a promising formulation approach to improve the
solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. ASDs have …

Phase Behavior of Amorphous Solid Dispersions: Miscibility and Molecular Interactions

K Sarpal - 2019 - uknowledge.uky.edu
Over the past few decades, amorphous solid dispersions (ASDs) have been of great interest
to pharmaceutical scientists to address bioavailability issues associated with poorly water …

Amorphous solid dispersions (asds): The influence of material properties, manufacturing processes and analytical technologies in drug product development

R Iyer, V Petrovska Jovanovska, K Berginc, M Jaklič… - Pharmaceutics, 2021 - mdpi.com
Poorly water-soluble drugs pose a significant challenge to developability due to poor oral
absorption leading to poor bioavailability. Several approaches exist that improve the oral …

Insights on the Dissolution Evaluation and Optimization of Amorphous Solid Dispersions

Z Wang - 2022 - search.proquest.com
Amorphous solid dispersions (ASDs) are an attractive approach to enhance solubility and
improve the dissolution of poorly soluble crystalline drugs in recent decades. In the ASDs …

Recent advances in amorphous solid dispersions: preformulation, formulation strategies, technological advancements and characterization

S Tambe, D Jain, SK Meruva, G Rongala, A Juluri… - Pharmaceutics, 2022 - mdpi.com
Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …

Characterization of amorphous solid dispersions

X Liu, X Feng, RO Williams, F Zhang - Journal of Pharmaceutical …, 2018 - Springer
The study of amorphous solid dispersions (ASDs) is currently one of the most exciting areas
in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the …

[图书][B] A mechanistic study to identify physically stable amorphous solid dispersion

M Vasanthavada - 2004 - search.proquest.com
Amorphous solid dispersions are known to improve the oral bioavailability of poorly water-
soluble drugs. However, the physical instability of solid dispersions leading to phase …