Synthesis of thymidine dimers containing a new internucleosidic amide linkage and their incorporation into oligodeoxyribonucleotides
L De Napoli, A Iadonisi, D Montesarchio… - Bioorganic & Medicinal …, 1995 - Elsevier
The synthesis of thymidine dimers 5a, b containing a chiral carbon in the propionamide
internucleosidic linkage is described. These new epimeric dimers were incorporated in …
internucleosidic linkage is described. These new epimeric dimers were incorporated in …
Incorporation of amide linked thymidine dimers into oligodeoxynucleotides
G Viswanadham, GV Petersen, J Wengel - Bioorganic & Medicinal …, 1996 - Elsevier
The synthesis of thymidine dimers in which the phosphodiester linkage has been replaced
by an amide linkage containing diamines (homopiperazine, 2, 5-trans-dimethylpiperazine …
by an amide linkage containing diamines (homopiperazine, 2, 5-trans-dimethylpiperazine …
Synthesis of oligodeoxyribonucleotides containing dimers with carbamate moieties as replacement of the natural phosphodiester linkage
A Waldner, A De Mesmaeker, J Lebreton - Bioorganic & Medicinal …, 1994 - Elsevier
The synthesis of thymidine dimers containing both possible regioisomeric carbamate
moieties in place of the natural phosphodiester backbone is described. These dimers were …
moieties in place of the natural phosphodiester backbone is described. These dimers were …
Synthesis of thymidine dimer derivatives containing an amide linkage and their incorporation into oligodeoxyribonucleotides
J Lebreton, A De Mesmaeker, A Waldner, V Fritsch… - Tetrahedron letters, 1993 - Elsevier
The syntheses of thymidine dimers in which the natural phosphodiester linkage has been
replaced by an amide group (3′-NR-CO-CH 2-5′; R= H, Me, n-Pr) are described. These …
replaced by an amide group (3′-NR-CO-CH 2-5′; R= H, Me, n-Pr) are described. These …
Synthesis of dinucleotides containing nitrone, hydroxylamine and amidoxime linkages
JK Gallos, CC Dellios - Tetrahedron letters, 2003 - Elsevier
Three new thymidine dinucleotides with nitrone, hydroxylamine and amidoxime backbone
linkages, suitable for incorporation into oligonucleotide chains, were easily synthesized, by …
linkages, suitable for incorporation into oligonucleotide chains, were easily synthesized, by …
Synthesis and hybridization properties of amide-linked thymidine dimers incorporated into oligodeoxynucleotides
I Idziak, G Just, MJ Damha, PA Giannaris - Tetrahedron letters, 1993 - Elsevier
Thymidine dimers, connected by amide or N-methyl amide linkages, have been prepared.
The dimers have each been incorporated three times into normal strands of DNA by solid …
The dimers have each been incorporated three times into normal strands of DNA by solid …
Synthesis of thymidine dimers containing piperazine in the internucleoside linkage and their incorporation into oligodeoxynucleotides
GV Petersen, J Wengel - Tetrahedron, 1995 - Elsevier
The synthesis of thymidine dimers in which the natural phosphodiester linkage has been
replaced by piperazine (3′-(N (CH2CH2) 2N)-5′, 9 and 3′-(N (CH2CH2) 2N)-CO-4 …
replaced by piperazine (3′-(N (CH2CH2) 2N)-5′, 9 and 3′-(N (CH2CH2) 2N)-CO-4 …
Synthesis of novel N-substituted guanidine linked nucleoside dimers and their incorporation into oligonucleotides
F Vandendriessche, M Voortmans… - Bioorganic & Medicinal …, 1993 - Elsevier
Dimer building blocks (5a-j) with an N substituted guanideine function were prepared by
reaction of 5'-amino-5'-deoxythymidine (1) with S, S-dimethyl-N substituted …
reaction of 5'-amino-5'-deoxythymidine (1) with S, S-dimethyl-N substituted …
Synthesis and hybridization studies of urea and carbamate linked thymidine dimers incorporated into oligodeoxynucleosides
KMK Kutterer, G Just - Bioorganic & Medicinal Chemistry Letters, 1994 - Elsevier
An efficient synthesis of urea, N-methyl urea and carbamate linked thymidine dimers has
been accomplished. Incorporation of the dimers one or three times into a DNA …
been accomplished. Incorporation of the dimers one or three times into a DNA …
4′, 6′-Methano carbocyclic thymidine: A conformationally constrained building block for oligonucleotides
KH Altmann, R Kesselring, E Francotte, G Rihs - Tetrahedron letters, 1994 - Elsevier
The synthesis of the title compound 1 has been accomplished in 20 chemical steps starting
from D-ribonolactone. X-ray crystallography shows the bicyclic skeleton of 1 to adopt a boat …
from D-ribonolactone. X-ray crystallography shows the bicyclic skeleton of 1 to adopt a boat …