The effects of aging on the immune system are manifest at multiple levels that include
reduced production of B and T cells in bone marrow and thymus and diminished function of …

Background Natural killer (NK) cells are cytotoxic lymphocytes that lack CD3 and express
variable levels of CD16, CD56 and CD57. In recent years NK cells have been categorised …

Review of the current understanding of age-dependent changes in leukocyte function and
their contribution to aging-related disease processes. Aging is associated with a progressive …

The world's population is aging, which brings about huge scientific challenges. Since the
biological process of aging is by far the greatest risk factor for most chronic diseases …

Sarcopenia, a geriatric syndrome that is characterized by a progressive and generalized
skeletal muscle disorder, can be associated with many comorbidities, including obesity …

The capability to cope with infectious agents and cancer cells resides not only in adaptive
immune responses against specific antigens, mediated by T and B lymphocytes clonally …

Adaptive immunity undergoes severe deterioration with age and represents the main
problem in the elderly. However, evidence accumulated over the last decade supports the …

The reduced efficiency of the mammalian immune system with aging increases host
susceptibility to infectious and autoimmune diseases. However, the mechanisms …

TNF-α-mediated apoptosis is enhanced in aged rodent muscles, suggesting that this
pathway may be involved in sarcopenia. Interleukin-15 (IL-15), a muscle-derived anabolic …

Interleukin-6 is a pleiotropic cytokine regulating different tissues and organs in diverse and
sometimes discrepant ways. The dual and sometime hermetic nature of IL-6 action has been …