The role of complement system in adipose tissue-related inflammation

SI Vlaicu, A Tatomir, D Boodhoo, S Vesa… - Immunologic …, 2016 - Springer
As the common factor linking adipose tissue to the metabolic context of obesity, insulin
resistance and atherosclerosis are associated with a low-grade chronic inflammatory status …

The complement system in human cardiometabolic disease

E Hertle, CDA Stehouwer… - Molecular immunology, 2014 - Elsevier
The complement system has been implicated in obesity, fatty liver, diabetes and
cardiovascular disease (CVD). Complement factors are produced in adipose tissue and …

Complement components, C3 and C4, and the metabolic syndrome

M Copenhaver, CY Yu, RP Hoffman - Current diabetes reviews, 2019 - ingentaconnect.com
Introduction: Increased systemic inflammation plays a significant role in the development of
adult cardiometabolic diseases such as insulin resistance, dyslipidemia, atherosclerosis …

The role of complement factor C3 in lipid metabolism

A Barbu, OA Hamad, L Lind, KN Ekdahl, B Nilsson - Molecular immunology, 2015 - Elsevier
Abundant reports have shown that there is a strong relationship between C3 and C3a-
desArg levels, adipose tissue, and risk factors for cardiovascular disease, metabolic …

Complement 3 serum levels as a pro-inflammatory biomarker for insulin resistance in obesity

RMAH Ahmad, HA Al-Domi - … & Metabolic Syndrome: Clinical Research & …, 2017 - Elsevier
Introduction Obesity is frequently characterized by chronic inflammation and insulin
resistance (IR). Obesity-associated inflammation is responsible for the complement system …

Alterations of the classic pathway of complement in adipose tissue of obesity and insulin resistance

J Zhang, W Wright, DA Bernlohr… - American Journal …, 2007 - journals.physiology.org
Adipose tissue inflammation has recently been linked to the pathogenesis of obesity and
insulin resistance. C1 complex comprising three distinct proteins, C1q, C1r, and C1s …

The emerging role of complement C3 as a biomarker of insulin resistance and cardiometabolic diseases: preclinical and clinical evidence

F Ursini, L Abenavoli - Reviews on recent clinical trials, 2018 - ingentaconnect.com
Background: An intricate network of reciprocal interactions between adipose tissue and
immune system have been largely demonstrated, leading to the well-accepted concept of …

The complement system is dysfunctional in metabolic disease: Evidences in plasma and adipose tissue from obese and insulin resistant subjects

JM Moreno-Navarrete, JM Fernández-Real - Seminars in cell & …, 2019 - Elsevier
The relationship among chronic low-grade inflammation, insulin resistance and other
obesity-associated metabolic disturbances is increasingly recognized. The possible …

C3 and C4 are strongly related to adipose tissue variables and cardiovascular risk factors

B Nilsson, OA Hamad, H Ahlström… - European journal of …, 2014 - Wiley Online Library
Background In several reports, C3 and C4 have been linked to diabetes and cardiovascular
disease (CVD). Here, we investigate this link and the degree of C3 activation in elderly …

[HTML][HTML] Complement activation in obesity, insulin resistance, and type 2 diabetes mellitus

K Shim, R Begum, C Yang, H Wang - World journal of diabetes, 2020 - ncbi.nlm.nih.gov
Amplified inflammatory reaction has been observed to be involved in cardiometabolic
diseases such as obesity, insulin resistance, diabetes, dyslipidemia, and atherosclerosis …