The central nervous system has enormously complex cellular diversity with hundreds of
distinct cell types, yet alternative splicing features in single cells of important cell types at …

Dysregulation of alternative splicing has been repeatedly associated with
neurodevelopmental disorders, but the extent of cell-type-specific splicing in human neural …

Although alternative splicing is a fundamental and pervasive aspect of gene expression in
higher eukaryotes, it is often omitted from single-cell studies due to quantification challenges …

The enormous cellular diversity in the mammalian brain, which is highly prototypical and
organized in a hierarchical manner, is dictated by cell-type–specific gene-regulatory …

Alternative splicing of pre-mRNAs expands the coding abilities of genomes by generating
distinct transcription variants from individual genes. It contributes to the marvelous …

Profiling gene expression in single neurons using single-cell RNA-Seq is a powerful method
for understanding the molecular diversity of the nervous system. Profiling alternative splicing …

Motivation: Gene expression and alternative splicing are strictly regulated processes that
shape brain development and determine the cellular identity of differentiated neural cell …

Alternative splicing (AS) generates isoform diversity for cellular identity and homeostasis in
multicellular life. Although AS variation has been observed among single cells, little is …

Regulation of gene expression is critical for fate commitment of stem and progenitor cells
during tissue formation. In the context of mammalian brain development, a plethora of …

Background Alternative splicing, which produces multiple mRNAs from a single gene,
occurs in most human genes and contributes to protein diversity. Many alternative isoforms …