Effect of Macrophage Overexpression of Murine Liver X Receptor-α (LXR-α) on Atherosclerosis in LDL-Receptor Deficient Mice
D Teupser, D Kretzschmar, C Tennert… - … , and vascular biology, 2008 - Am Heart Assoc
Background—The nuclear liver X receptor-α (LXR-α) has been implicated in the regulation
of intracellular cholesterol homeostasis, inflammatory response, and atherosclerosis …
of intracellular cholesterol homeostasis, inflammatory response, and atherosclerosis …
[HTML][HTML] Ligand activation of LXRβ reverses atherosclerosis and cellular cholesterol overload in mice lacking LXRα and apoE
MN Bradley, C Hong, M Chen… - The Journal of …, 2007 - Am Soc Clin Investig
Liver X receptors (LXRs) α and β are transcriptional regulators of cholesterol homeostasis
and potential targets for the development of antiatherosclerosis drugs. However, the specific …
and potential targets for the development of antiatherosclerosis drugs. However, the specific …
Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists
N Levin, ED Bischoff, CL Daige, D Thomas… - … , and vascular biology, 2005 - Am Heart Assoc
Objective—Complications of atherosclerotic cardiovascular disease due to elevated blood
cholesterol levels are the major cause of death in the Western world. The liver X receptors …
cholesterol levels are the major cause of death in the Western world. The liver X receptors …
Identification of macrophage liver X receptors as inhibitors of atherosclerosis
RK Tangirala, ED Bischoff, SB Joseph… - Proceedings of the …, 2002 - National Acad Sciences
Recent studies have identified the liver X receptors (LXRα and LXRβ) as important
regulators of cholesterol metabolism and transport. LXRs control transcription of genes …
regulators of cholesterol metabolism and transport. LXRs control transcription of genes …
Activation of Liver X Receptor Decreases Atherosclerosis in Ldlr−/− Mice in the Absence of ATP-Binding Cassette Transporters A1 and G1 in Myeloid Cells
MS Kappus, AJ Murphy, S Abramowicz… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Liver X receptor (LXR) activators decrease atherosclerosis in mice. LXR
activators (1) directly upregulate genes involved in reverse cholesterol transport and (2) …
activators (1) directly upregulate genes involved in reverse cholesterol transport and (2) …
Macrophage LXRα gene therapy ameliorates atherosclerosis as well as hypertriglyceridemia in LDLR−/− mice
G Li, KC Biju, X Xu, Q Zhou, C Chen, AJ Valente, W He… - Gene therapy, 2011 - nature.com
Liver X receptors (LXRs) are implicated in the regulation of cholesterol homeostasis,
inflammatory response and atherogenesis. Administration of LXR agonists inhibits the …
inflammatory response and atherogenesis. Administration of LXR agonists inhibits the …
Expression of the LXRα protein in human atherosclerotic lesions
Y Watanabe, S Jiang, W Takabe, R Ohashi… - … , and vascular biology, 2005 - Am Heart Assoc
Objective—Liver X–activated receptor α (LXRα) regulates multiple genes controlling
cholesterol metabolism and transport. To clarify its role in atherogenesis, we established a …
cholesterol metabolism and transport. To clarify its role in atherogenesis, we established a …
Liver X receptor (LXR)-β regulation in LXRα-deficient mice: implications for therapeutic targeting
EM Quinet, DA Savio, AR Halpern, L Chen… - Molecular …, 2006 - ASPET
The nuclear receptors liver X receptor (LXR) LXRα and LXRβ are differentially expressed
ligand-activated transcription factors that induce genes controlling cholesterol homeostasis …
ligand-activated transcription factors that induce genes controlling cholesterol homeostasis …
Non-redundant roles for LXRα and LXRβ in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice [S]
ED Bischoff, CL Daige, M Petrowski, H Dedman… - Journal of lipid …, 2010 - ASBMB
The liver X receptors LXRα and LXRβ play critical roles in maintaining lipid homeostasis by
functioning as transcription factors that regulate genetic networks controlling the transport …
functioning as transcription factors that regulate genetic networks controlling the transport …
Liver x receptor signaling pathways and atherosclerosis
AC Calkin, P Tontonoz - Arteriosclerosis, thrombosis, and vascular …, 2010 - Am Heart Assoc
First discovered as orphan receptors, liver X receptors (LXRs) were subsequently identified
as the nuclear receptor target of the cholesterol metabolites, oxysterols. There are 2 LXR …
as the nuclear receptor target of the cholesterol metabolites, oxysterols. There are 2 LXR …