Background: Recent evidence suggests that combining individual imaging markers of
cerebral small vessel disease (SVD) may more accurately reflect its overall burden and …

Purpose: Enlarged perivascular spaces (EPVS) have been widely considered as a feature of
cerebral small vessel disease (cSVD) but the pathogenesis of EPVS remains unclear …

Objective To investigate the 2-year change in parenchymal diffusivity, a quantitative marker
of microstructural tissue condition, and the relationship with baseline blood-brain barrier …

Blood-brain barrier (BBB) disruption has long been recognised as an important early feature
of multiple sclerosis (MS) pathology. Traditionally, this has been seen as a by-product of the …

Background and Purpose—The etiology of cerebral small vessel disease is unknown. An
association with endothelial dysfunction has been suggested. We systematically assessed …

Microinfarcts occur commonly in the aging brain as a consequence of diffuse embolic events
and are associated with the development of vascular dementia and Alzheimer9s disease …

Cerebral small vessel disease (CSVD) is a generic term used for intracranial vascular
disorders caused by the structural changes of cerebral microvessels, including the small …

Cerebral small vessel disease (SVD) is a heterogeneous group of pathological disorders
that affect the small vessels of the brain and are an important cause of cognitive impairment …

Cerebral small vessel disease (SVD) contributes to 25% of ischemic strokes and 45% of
dementias. We aimed to investigate the role of cerebral blood flow (CBF) and intracranial …

Introduction Diffusion tensor imaging detects early tissue alterations in Alzheimer's disease
and cerebral small vessel disease (SVD). However, the origin of diffusion alterations in SVD …