Background Alzheimer's disease (AD) is a devastating neurodegenerative disorder that
affects a large and growing number of elderly individuals. In addition to idiopathic disease …

Alzheimer's disease (AD) is the most common cause of dementia and understanding its
pathogenesis should lead to improved therapeutic and diagnostic methods. Although …

Alzheimer's disease (AD) is a multigenic neurodegenerative disorder characterized by
distinct neuropathological hallmarks including deposits of the β-amyloid (Aβ) peptide. Aβ is …

Transgenic (Tg) mice that overexpress mutant familial Alzheimer's disease (AD) amyloid
precursor protein (APP) genes have contributed to an understanding of dementia pathology …

Alzheimer's disease (AD) is histopathologically characterized by neurodegeneration, the
formation of intracellular neurofibrillary tangles and extracellular Aβ deposits that derive from …

The accumulation of beta‐amyloid protein in specific brain regions is a central pathological
feature of Alzheimer's disease (AD). The 4 kd beta‐amyloid protein derives from a larger …

The β-amyloid precursor protein (APP) carries mutations in codons 717 or 670/671, which
cosegregate with familial forms of Alzheimer's disease (AD). As an initial step to study the …

Mutations in the amyloid precursor protein (APP) gene are associated with altered
production and deposition of amyloid beta (Aβ) peptide in the Alzheimer's disease (AD) …

Transgenic mouse models of Alzheimer's disease (AD) expressing high levels of amyloid
precursor protein (APP) with familial AD (FAD) mutations have proven to be extremely useful …

Transgenic mice overexpressing different forms of amyloid precursor protein (APP), ie wild
type or clinical mutants, displayed an essentially comparable early phenotype in terms of …