The environmental pathogen Cryptococcus neoformans claims over 180,000 lives each
year. Survival of this basidiomycete at host CO 2 concentrations has only recently been …

Cryptococcus neoformans kills 200,000 people worldwide each year. After inhalation, this
environmental yeast proliferates either extracellularly or within host macrophages. Under …

A common feature shared by systemic fungal pathogens of environmental origin, such as
Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In …

Cryptococcus neoformans survives host temperature and regulates cell wall integrity via a
calcium-dependent phosphatase, calcineurin. However, downstream effectors of C …

To aerobic organisms, low oxygen tension (hypoxia) presents a physiological challenge. To
cope with such a challenge, metabolic pathways such as those used in energy production …

The human fungal pathogen Cryptococcus neoformans relies on a complex signaling
network for the adaptation and survival at the host temperature. Protein phosphatase …

Cryptococcus neoformans is a basidiomycetous yeast responsible for hundreds of
thousands of deaths a year and is particularly threatening in immunocompromised patients …

Cryptococcus neoformans encounters a low oxygen environment when it enters the human
host. Here, we show that the conserved Ras1 (a small GTPase) and Cdc24 (the guanine …

The opportunistic human fungal pathogen Cryptococcus neoformans has tremendous
impact on global health, causing 181,000 deaths annually. Current treatment options are …

Across lower eukaryotes, the transcription factor Crz1 is dephosphorylated by calcineurin,
which facilitates Crz1 translocation to the nucleus to regulate gene expression. In the fungal …