Infantile spasms: criteria for an animal model
CE Stafstrom, GL Holmes - International review of neurobiology, 2002 - Elsevier
Infantile spasms is an epilepsy syndrome with several distinctive features, including age
specificity during infancy, characteristic semiology (epileptic spasms), specific …
specificity during infancy, characteristic semiology (epileptic spasms), specific …
Infantile spasms: hypothesis-driven therapy and pilot human infant experiments using corticotropin-releasing hormone receptor antagonists
TZ Baram, WG Mitchell, K Brunson… - Developmental …, 1999 - karger.com
Abstract Background and Rationale: Infantile spasms (IS) are an age-specific seizure
disorder occurring in 1: 2,000 infants and associated with mental retardation in∼ 90% of …
disorder occurring in 1: 2,000 infants and associated with mental retardation in∼ 90% of …
[HTML][HTML] On the basic mechanisms of infantile spasms
JW Swann, SL Moshe - 2012 - europepmc.org
Infantile spasms is an unusual seizure disorder. The seizures themselves are only a few
seconds in duration and consist of brief flexion and/or extension jerking movements. EEG …
seconds in duration and consist of brief flexion and/or extension jerking movements. EEG …
Animal models in epileptic spasms and the development of novel treatment options
KT Barrett, A Choudhary, B Charkhand… - Journal of Clinical …, 2022 - journals.lww.com
The infantile spasms (IS) syndrome is a catastrophic developmental epileptic
encephalopathy syndrome characterized by an age-specific expression of epileptic spasms …
encephalopathy syndrome characterized by an age-specific expression of epileptic spasms …
Validation of the rat model of cryptogenic infantile spasms
Purpose: To determine whether a new model of cryptogenic infantile spasms consisting of
prenatal priming with betamethasone and postnatal trigger of spasms by N‐methyl‐d …
prenatal priming with betamethasone and postnatal trigger of spasms by N‐methyl‐d …
A new animal model of infantile spasms with unprovoked persistent seizures
CL Lee, JD Frost Jr, JW Swann, RA Hrachovy - Epilepsia, 2008 - Wiley Online Library
Purpose: Infantile spasms is one of the most severe epileptic syndromes of infancy and early
childhood. Progress toward understanding the pathophysiology of this disorder and the …
childhood. Progress toward understanding the pathophysiology of this disorder and the …
Treatment of infantile spasms: emerging insights from clinical and basic science perspectives
CE Stafstrom, BGW Arnason, TZ Baram… - Journal of child …, 2011 - journals.sagepub.com
Infantile spasms is an epileptic encephalopathy of early infancy with specific clinical and
electroencephalographic (EEG) features, limited treatment options, and a poor prognosis …
electroencephalographic (EEG) features, limited treatment options, and a poor prognosis …
Basic mechanisms of catastrophic epilepsy–overview from animal models
AS Galanopoulou - Brain and Development, 2013 - Elsevier
Infantile spasms are age-specific seizures of infantile epileptic encephalopathies that are
usually associated with poor epilepsy and neurodevelopmental outcomes. The current …
usually associated with poor epilepsy and neurodevelopmental outcomes. The current …
A potential effect of ganaxolone in an animal model of infantile spasms
MS Yum, M Lee, TS Ko, L Velíšek - Epilepsy research, 2014 - Elsevier
Rationale Infantile spasms (IS), a devastating epileptic encephalopathy of infancy, involve
various etiologies associated with an unknown underlying common pathophysiology. The …
various etiologies associated with an unknown underlying common pathophysiology. The …
Model of cryptogenic infantile spasms after prenatal corticosteroid priming
Infantile spasms (IS) is a devastating epilepsy syndrome of childhood. IS occurs in 3–12‐
month‐old infants and is characterized by spasms, interictal electroencephalography (EEG) …
month‐old infants and is characterized by spasms, interictal electroencephalography (EEG) …