β‐and γ‐cytoplasmic actin are nearly indistinguishable in their amino acid sequence, but are
encoded by different genes that play non‐redundant biological roles. The key determinants …

β-and γ-cytoplasmic actins are ubiquitously expressed in every cell type and are nearly
identical at the amino acid level but play vastly different roles in vivo. Their essential roles in …

Vertebrate nonmuscle cells express two actin isoforms: cytoplasmic β-and γ-actin. Because
of the presence and localized translation of β-actin at the leading edge, this isoform is …

Cytoplasmic actins are abundant, ubiquitous proteins in nucleated cells. However, actin
expression is regulated in a tissue-and development-specific manner. We identified a novel …

Ubiquitously expressed β-actin and γ-actin isoforms play critical roles in most cellular
processes; however, their unique contributions are not well understood. We generated …

The actin cytoskeleton plays key roles in every eukaryotic cell and is essential for cell
adhesion, migration, mechanosensing, and contractility in muscle and non-muscle tissues …

Actin is one of the most abundant intracellular proteins, essential in every eukaryotic cell
type. Actin plays key roles in tissue morphogenesis, cell adhesion, muscle contraction, and …

Although a large number of actin-binding proteins and their regulators have been identified
through classical approaches, gaps in our knowledge remain. Here, we used genome-wide …

Actin is one of the most abundant and essential intracellular proteins that mediates nearly
every form of cellular movement and underlies such key processes as embryogenesis …

The highly homologous β (βcyto) and γ (γcyto) cytoplasmic actins are hypothesized to carry
out both redundant and unique essential functions, but studies using targeted gene …