Serine Proteinases Mimics: Hydrolytic Activity of Cyclic Peptides Which Include a Non-natural
Amino Acid t Page 1 Tvrrnhrdrorl Lerreu, Vol. 36, No. 49. pp X987-8990, 1995 Elsevier Scmm …

" Catalysis by an enzyme requires the specific binding of one or more substrate molecules to
a catalytic site and a chemical interaction with this site, which may directly utilize the binding …

Proteinases are known to play a crucial role in the normal functioning of biological systems
(Holzer and Tschesche, 1979). They are involved in important processes such as food …

Two cyclic peptides cyclo (Phe‐MeAnt‐Glyn) with MeAnt= 5‐methyl‐anthranilic acid residue,
n= 4 (3b) and n= 6 (4b), have been synthesized in solution and their reaction with α …

A dipeptide seryl-histidine (Ser-His) was found to have theprotein cleavage activity. BSA
was cleaved into smear at aroundpH 5.0–6.0, with a half-life around 15 hr at 60° C …

As a result of about thirty years of intensive study, most especially concentrated on bovine
chymotrypsin because of its ready availability, the mode of operation of these enzymes is …

Abstract Prostate‐specific antigen (PSA), a member of the kallikrein sub‐group of the trypsin
serine protease family, is a widely used marker for prostate cancer. Several sequences with …

Publisher Summary This chapter focuses on the thioester peptide chloromethyl ketones that
are the reagents for active site-selective labeling of serine proteinases with spectroscopic …

Publisher Summary Aza-amino acid residues are analogs of amino acids in which the α-CH
has been replaced by a nitrogen atom. This substitution has a profound effect on the …

The serine proteases comprise a large group of enzymes which is distinguished by the
reactivity of a serine residue in the active site. 1 A common test for these enzymes is the …