The vast majority of thyroid cancers of follicular origin (TC) have a very favourable outcome,
but 5–10% of cases will develop metastatic disease. Around 60–70% of this subset, hence …

Simple Summary The Ras-Raf-MEK-ERK signaling pathway is responsible for regulating
cell proliferation, differentiation and survival. Overexpression and overactivation of members …

Whole genome sequencing approaches have provided unprecedented insights into the
genetic lesions responsible for the onset, progression and dedifferentiation of various types …

Purpose: The purpose of the study was to explore optimal combinations of currently actively
developed drugs for dually targeting the Ras→ Raf→ MAPK kinase (MEK)→ MAPK/ERK …

The spectrum of thyroid cancers ranges from one of the most indolent to one of the most
aggressive solid tumors identified. Conventional therapies for thyroid cancers are based on …

The number of thyroid cancers is increasing. Standard treatment usually includes primary
surgery, thyroid-stimulating hormone suppressive therapy, and ablation of the thyroid …

Purpose: In thyroid cancer clinical trials, agents targeting VEGF receptors (VEGFR) and
RET, among other kinases, have led to partial responses but few complete or durable …

Thyroid carcinomas are rare and heterogeneous diseases representing less than 1% of all
malignancies. The majority of thyroid carcinomas are differentiated entities (papillary and …

Thyroid cancer is a common malignancy of endocrine system, and has now become the
fastest increasing cancer among all the malignancies. The development, progression …

Thyroid cancer is the most common endocrine cancer. The discovery of new biomarkers for
thyroid cancer has significantly improved the understanding of the molecular pathogenesis …