Diabetes mellitus can cause dysfunction of the central nervous system called “diabetic
encephalopathy”. Although various oral drugs are used to treat diabetes, they do not prevent …

Abstract Luteolin (3', 4', 5, 7-tetrahydroxyflavone) has powerful anti-apoptotic and antioxidant
properties. This study aimed to investigate the effects of luteolin on hyperglycemia-mediated …

Luteolin, a flavonoid isolated from Cirsium japonicum, has antioxidant, anti-inflammatory
and neuroprotective activities. Our previous studies brought a prospect that luteolin …

The epidemic and experimental studies have confirmed that the obesity can lead to
neuroinflammation, neurodegenerative diseases and adversely affect cognition. Despite the …

Diabetes-induced learning and memory impairment, characterized by impaired cognitive
functions and neurochemical and structural abnormalities, involve direct neuronal damage …

In the present study, the protective effects of luteolin were investigated against psychological
stress-induced cognitive impairment. To emulate the psychological stress, mice received …

Published studies have shown that cognitive deficit is a characteristic manifestation of
neurodegenerative disease in diabetes. However, there is no effective prevention and …

Diabetes-induced damages in brain are known as diabetic encephalopathy, which is well
characterized by cellular, molecular and functional changes in the brain of diabetic subjects …

Peripheral neuropathies are a major cause of morbidity in patients with diabetes mellitus. Up
to now, drugs for improving the impaired nerve functions has been lacking for diabetic …

Diabetes-related cognitive dysfunction is a consequence of changes within the central
nervous system that are secondary to chronic hyperglycemia, oxidative stress, and …