[HTML][HTML] Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer's disease

M Algamal, AN Russ, MR Miller, SS Hou… - Communications …, 2022 - nature.com
Alzheimer's disease (AD) is characterized by progressive memory loss and cognitive
decline. These impairments correlate with early alterations in neuronal network activity in AD …

[HTML][HTML] Long-term dynamics of aberrant neuronal activity in awake Alzheimer's disease transgenic mice

V Korzhova, P Marinković, JR Njavro… - Communications …, 2021 - nature.com
Alzheimer's disease (AD) is associated with aberrant neuronal activity, which is believed to
critically determine disease symptoms. How these activity alterations emerge, how stable …

[HTML][HTML] Inhibitory neuron and hippocampal circuit dysfunction in an aged mouse model of Alzheimer's disease

A Hazra, F Gu, A Aulakh, C Berridge, JL Eriksen… - PloS one, 2013 - journals.plos.org
In Alzheimer's disease (AD), a decline in explicit memory is one of the earliest signs of
disease and is associated with hippocampal dysfunction. Amyloid protein exerts a disruptive …

[HTML][HTML] Dysfunction of somatostatin-positive interneurons associated with memory deficits in an Alzheimer's disease model

LC Schmid, M Mittag, S Poll, J Steffen, J Wagner… - Neuron, 2016 - cell.com
Alzheimer's disease (AD) is characterized by cognitive decline and neuronal network
dysfunction, but the underlying mechanisms remain unknown. In the hippocampus …

[HTML][HTML] Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer's disease

S Hijazi, TS Heistek, P Scheltens, U Neumann… - Molecular …, 2020 - nature.com
Neuronal network dysfunction is increasingly recognized as an early symptom in
Alzheimer's disease (AD) and may provide new entry points for diagnosis and intervention …

[HTML][HTML] Analysis of age-dependent alterations in excitability properties of CA1 pyramidal neurons in an APPPS1 model of Alzheimer's disease

P Vitale, AR Salgueiro-Pereira, CA Lupascu… - Frontiers in aging …, 2021 - frontiersin.org
Age-dependent accumulation of amyloid-β, provoking increasing brain amyloidopathy,
triggers abnormal patterns of neuron activity and circuit synchronization in Alzheimer's …

Novel quantitative analyses of spontaneous synaptic events in cortical pyramidal cells reveal subtle parvalbumin-expressing interneuron dysfunction in a knock-in …

L Chen, T Saito, TC Saido, I Mody - eneuro, 2018 - eneuro.org
Alzheimer's disease (AD) is a neurodegenerative disorder that has become a compelling
global public health concern. Besides pathological hallmarks such as extracellular amyloid …

Reduced firing rates of pyramidal cells in the frontal cortex of APP/PS1 can be restored by acute treatment with levetiracetam

JL Klee, AJ Kiliaan, A Lipponen, FP Battaglia - Neurobiology of Aging, 2020 - Elsevier
In recent years, aberrant neural oscillations in various cortical areas have emerged as a
common physiological hallmark across mouse models of amyloid pathology and patients …

[HTML][HTML] Differences in synaptic dysfunction between rTg4510 and APP/PS1 mouse models of Alzheimer's disease

S Gelman, J Palma, G Tombaugh… - Journal of Alzheimer's …, 2018 - content.iospress.com
Genetically modified mice have provided insights into the progression and pathology of
Alzheimer's disease (AD). Here, we have examined two mouse models of AD: the rTg4510 …

Neuronal hyperexcitability in APP SWE/PS1dE9 mouse models of Alzheimer's disease

L Müller, T Kirschstein, R Köhling… - Journal of …, 2021 - content.iospress.com
Transgenic mouse models serve a better understanding of Alzheimer's disease (AD)
pathogenesis and its consequences on neuronal function. Well-known and broadly used AD …