Tumor hypoxia imaging

X Sun, G Niu, N Chan, B Shen, X Chen - Molecular Imaging and Biology, 2011 - Springer
There is a need to measure tumor hypoxia in assessing the aggressiveness of tumor and
predicting the outcome of therapy. A number of invasive and noninvasive techniques have …

The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities

JC Walsh, A Lebedev, E Aten, K Madsen… - Antioxidants & redox …, 2014 - liebertpub.com
Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …

Functional imaging of intratumoral hypoxia

SS Foo, DF Abbott, N Lawrentschuk… - Molecular Imaging & …, 2004 - Elsevier
PURPOSE: Tumor hypoxia plays a fundamental role in tumor progression and treatment
resistance. Recent evidence that hypoxia also influences the regulation and transcription of …

Clinical and pre-clinical methods for quantifying tumor hypoxia

AG Rickard, GM Palmer, MW Dewhirst - Hypoxia and Cancer Metastasis, 2019 - Springer
Hypoxia, a prevalent characteristic of most solid malignant tumors, contributes to diminished
therapeutic responses and more aggressive phenotypes. The term hypoxia has two …

Molecular imaging of hypoxia with radiolabelled agents

G Mees, R Dierckx, C Vangestel… - European journal of …, 2009 - Springer
Tissue hypoxia results from an inadequate supply of oxygen (O 2) that compromises
biological functions. Structural and functional abnormalities of the tumour vasculature …

[HTML][HTML] The meaning, measurement and modification of hypoxia in the laboratory and the clinic

EM Hammond, MC Asselin, D Forster, JPB O'Connor… - Clinical oncology, 2014 - Elsevier
Hypoxia was identified as a microenvironmental component of solid tumours over 60 years
ago and was immediately recognised as a potential barrier to therapy through the reliance of …

Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy

JL Tatum - International journal of radiation biology, 2006 - Taylor & Francis
Purpose: The Cancer Imaging Program of the National Cancer Institute convened a
workshop to assess the current status of hypoxia imaging, to assess what is known about the …

Molecular mechanisms of hypoxia in cancer

A Challapalli, L Carroll, EO Aboagye - Clinical and translational imaging, 2017 - Springer
Purpose Hypoxia is a condition of insufficient oxygen to support metabolism which occurs
when the vascular supply is interrupted, or when a tumour outgrows its vascular supply. It is …

Imaging of hypoxia using PET and MRI

FC Gaertner, M Souvatzoglou, G Brix… - Current …, 2012 - ingentaconnect.com
Tumor hypoxia is the result of an inadequate supply of oxygen to tumor cells which can be
caused by multiple factors. It is associated with aggressive local tumor growth and invasion …

Tumor hypoxia: causative mechanisms, microregional heterogeneities, and the role of tissue-based hypoxia markers

P Vaupel, A Mayer - Oxygen Transport to Tissue XXXVIII, 2016 - Springer
Tumor hypoxia is a hallmark of solid malignant tumor growth, profoundly influences
malignant progression and contributes to the development of therapeutic resistance …