A multimodel regime for evaluating effectiveness of antimicrobial wound care products in microbial biofilms

JJ Stoffel, PL Kohler Riedi… - Wound Repair and …, 2020 - Wiley Online Library
Microbial biofilms have become increasingly recognized as a cause of wound chronicity.
There are several topical antimicrobial wound care products available for use; however …

Anti-biofilm efficacy of commonly used wound care products in in vitro settings

M Regulski, MF Myntti, GA James - Antibiotics, 2023 - mdpi.com
Considering the prevalence and pathogenicity of biofilms in wounds, this study was
designed to evaluate the anti-biofilm capabilities of eight commercially available wound care …

Biofilm inhibitory and eradicating activity of wound care products against Staphylococcus aureus and Staphylococcus epidermidis biofilms in an in vitro chronic …

G Brackman, L De Meyer, HJ Nelis… - Journal of applied …, 2013 - academic.oup.com
Aims Although several factors contribute to wound healing, bacterial infections and the
presence of biofilm can significantly affect healing. Despite that this clearly indicates that …

A novel chronic wound biofilm model sustaining coexistence of Pseudomonas aeruginosa and Staphylococcus aureus suitable for testing of antibiofilm effect of …

X Chen, J Lorenzen, Y Xu, M Jonikaite… - Wound Repair and …, 2021 - Wiley Online Library
Chronic wounds are a large burden to patients and healthcare systems. Biofilm infections in
chronic wounds are crucial factors leading to non‐healing of wounds. It is important to study …

Modelling antisepsis using defined populations of facultative and anaerobic wound pathogens grown in a basally perfused biofilm model

A Oates, S Lindsay, H Mistry, F Ortega, AJ McBain - Biofouling, 2018 - Taylor & Francis
An in vitro model was developed to assess the effects of topical antimicrobials on
taxonomically defined wound biofilms. Biofilms were exposed over seven days to povidone …

Comparative analysis of biofilm models to determine the efficacy of antimicrobials

EK Stuermer, M Besser, F Brill, M Geffken… - International Journal of …, 2021 - Elsevier
Biofilms are one of the greatest challenges in today's treatment of chronic wounds. While
antimicrobials kill platonic bacteria within seconds, they are rarely able to harm biofilms. In …

The efficacy of topical agents used in wounds for managing chronic biofilm infections: A systematic review

S Schwarzer, GA James, D Goeres, T Bjarnsholt… - Journal of Infection, 2020 - Elsevier
Objectives Clinicians have increasingly adopted the widespread use of topical agents to
manage chronic wound infections, despite limited data on their effectiveness in vivo. This …

Effects of biofilm treatments on the multi-species Lubbock chronic wound biofilm model

SE Dowd, Y Sun, E Smith, JP Kennedy… - Journal of wound …, 2009 - magonlinelibrary.com
Objective: To evaluate the efficacy of several biofilm effectors in inhibiting biofilm formation
in an in vitro multi-species chronic wound biofilm model. Method: The Lubbock Chronic …

Challenges with wound infection models in drug development

SK Shukla, AK Sharma, V Gupta, A Kalonia… - Current drug …, 2020 - ingentaconnect.com
Wound research is an evolving science trying to unfold the complex untold mechanisms
behind the wound healing cascade. In particular, interest is growing regarding the role of …

In vitro Activity of Antimicrobial Wound Dressings on P. aeruginosa Wound Biofilm

EK Stuermer, I Plattfaut, M Dietrich, F Brill… - Frontiers in …, 2021 - frontiersin.org
The treatment of acute and chronic infected wounds with residing biofilm still poses a major
challenge in medical care. Interactions of antimicrobial dressings with bacterial load, biofilm …