Combining antagonist/partial agonist activity at dopamine D 2 and agonist activity at
serotonin 5-HT 1A receptors is one of the approaches that has recently been chosen to …

Apart from their differential propensities to block dopamine D2 and serotonin 5-HT2
receptors, the molecular mechanisms underlying the clinical efficacy of typical and atypical …

In a controlled trial, the β-adrenoceptor/5-hydroxytryptamine-1A (5-HT 1A) receptor
antagonist pindolol accelerated and enhanced the antidepressant effect of fluoxetine. The …

Fluoxetine, a serotonin (5-HT) reuptake inhibitor, has been documented to exert a protective
action against convulsive seizures in animal models, when administered either systemically …

Synopsis: Fluvoxamine 1 is a new antidepressant which potently and specifically inhibits
neuronal reuptake of serotonin. In the absence of other major pharmacological effects it …

Fluoxetine (Prozac) inhibited the membrane currents elicited by serotonin (5-
hydroxytryptamine; 5HT) in Xenopus oocytes expressing either cloned 5HT2C receptors or …

Abstract Fluoxetine is a selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor
(SSRI). Although its mechanism of action in anxiety disorders is unclear, it is thought to act …

Buspirone is a clinically efficacious anti-anxiety drug without any other benzodiazepine-like
activity. Although buspirone can displace ligands for dopamine (DA) receptors, its …

Sibutramine HCl is an inhibitor of the reuptake of monoamines with a pharmacological
profile in rodents indicative of antidepressant activity. The secondary (BTS 54 354) and …

Rationale The volatile anesthetic isoflurane is suggested to produce a rapid and robust
antidepressive effect in preliminary clinical trials. Recently, isoflurane was found to activate …