Common brain abnormalities in cortical morphology and functional organization are
observed in psychiatric disorders and aging, reflecting shared genetic influences. This …

Critical environmental factors like physical threats, air pollution, and infections, alongside
social determinants of health (SDH)(Ibáñez et al., 2023) such as social disparities …

With ever-increasing elder populations, age-related cognitive decline, which is
characterized as a gradual decline in cognitive capacity in the aging process, has turned out …

Both psychiatric vulnerability and cortical structure are shaped by the cumulative effect of
common genetic variants across the genome. However, the shared genetic underpinnings …

Background Parcellation of the cerebral cortex serves the investigation of the emergence of
uniquely human brain functions and disorders. Transcriptome data enable the …

Cytoarchitectural abnormalities have been described in the prefrontal cortex (PFC) of
subjects with psychiatric disorders. We explored the possible genetic causalities that may …

Major psychiatric disorders, including attention deficit hyperactivity disorder (ADHD), autism
(AUT), bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SZ), are …

Neuroinflammation has been implicated in multiple brain disorders but the extent and the
magnitude of change in immune-related genes (IRGs) across distinct brain disorders has not …

Human brain structure shows heterogeneous patterns of change across adults aging and is
associated with cognition. However, the relationship between cortical structural changes …

Background Mental health and cognitive achievement are partly heritable, highly polygenic,
and associated with brain variations in structure and function. However, the underlying …