Intrauterine growth restriction (IUGR) leads to obesity, glucose intolerance, and type 2
diabetes mellitus in the adult. To determine the mechanism (s) behind this “metabolic …

We examined the long-term effect of in utero exposure to streptozotocin-induced maternal
diabetes on the progeny that postnatally received either ad libitum access to milk by being …

To determine the cellular adaptations to fetal hyperglycemia and hypoglycemia, we
examined the time-dependent effects on basal (GLUT-1 and GLUT-3) and insulin …

Epidemiological and experimental studies have demonstrated that early postnatal nutrition
has been associated with long-term effects on glucose homeostasis in adulthood. Recently …

Skeletal muscle insulin resistance is a major characteristic underpinning type 2 diabetes.
Impairments in the insulin responsiveness of the glucose transporter, Glut4 (Slc2a4), have …

To determine the molecular mechanism (s) linking fetal adaptations in intrauterine growth
restriction (IUGR) to adult maladaptations of type 2 diabetes mellitus, we investigated the …

Employing Western blot analysis, we investigated the effect of maternal uterine artery
ligation causing uteroplacental insufficiency with asymmetrical intrauterine growth restriction …

The GLUT4 glucose transporter is primarily expressed in skeletal muscle, heart and adipose
tissue, where its expression is postnatal, coincident with the acquisition of insulin-regulated …

To determine mechanisms underlying the transgenerational presence of metabolic
perturbations in the intrauterine growth-restricted second-generation adult females (F2 …

Enhanced de novo lipogenesis (DNL), an adult hepatic adaption, is seen with high
carbohydrate or low-fat diets. We hypothesized that ad libitum intake after prenatal calorie …