Abstract A series of 1-methyl-3, 5-diphenyl-4, 5-dihydro-1H-pyrazoles (3a–k and 4a–u) were
designed, synthesized, and evaluated for their inhibitory efficacy towards the two hMAO …

Based on our recently reported selective hMAO-A inhibitors, on which, the intramolecular
cyclization led to a very interesting change of isoform selectivity. A series of selective hMAO …

In this study we synthesized and evaluated a new series of amino and nitro 3-arylcoumarins
as hMAO-A and hMAO-B inhibitors. Compounds 2, 3, 5 and 6 presented a better activity and …

Aim and Objective: MAO inhibitors have a significant effect on the nervous system since they
act in regulation of neurotransmitter concentrations. Neurotransmitter levels are critical for a …

In the recent works, it was shown that numerous thiazolylhydrazine derivatives display
hMAO inhibitory activity in the range of micromolar concentration. Hence, in the present …

Abstract Thirty seven novel 2-pyrazoline-1-ethanone derivatives were designed,
synthesized and evaluated as selective hMAO inhibitors. Among them, compounds 7h (IC …

Abstract A series of new 1, 3, 4-oxadiazole 3a-3k and hydrazone hybrids 5a-5m were
synthesized and their activity against both the A and B isoforms of hMAO was evaluated in …

Abstract A series of 2-(arylmethylidene)-2, 3-dihydro-1-benzofuran-3-one derivatives
(aurones, 1–20) were synthesized and screened for their inhibitory activity against hMAO …

The design of selective, reversible and non‐toxic hMAO− B inhibitors has received
increasing attention due to their perceived utility in targeting of neurological disorders like …

Abstract A series of 4-substituted-2-thiazolylhydrazone derivatives have been synthesized
and tested in vitro for their human monoamine oxidase (hMAO) A and B inhibitory activity …